PDB entry 8aex

View 8aex on RCSB PDB site
Description: Lipidic alpha-synuclein fibril - polymorph L3A
Class: protein fibril
Keywords: amyloid fibril, PROTEIN FIBRIL
Deposited on 2022-07-14, released 2022-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-11-23, with a file datestamp of 2022-11-18.
Experiment type: EM
Resolution: 2.76 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexa_
  • Chain 'B':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexb_
  • Chain 'C':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexc_
  • Chain 'D':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexd_
  • Chain 'E':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexe_
  • Chain 'F':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexf_
  • Chain 'G':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexg_
  • Chain 'H':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexh_
  • Chain 'I':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexi_
  • Chain 'J':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8aexj_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >8aexA (A:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexA (A:)
gvvaaatkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegag
siaaatgfvkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >8aexB (B:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexB (B:)
tkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaat
gfvkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >8aexC (C:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexC (C:)
gvvaaatkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegag
siaaatgfvkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >8aexD (D:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexD (D:)
tkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaat
gfvkk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >8aexE (E:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexE (E:)
gvvaaatkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegag
siaaatgfvkk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >8aexF (F:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexF (F:)
tkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaat
gfvkk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >8aexG (G:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexG (G:)
gvvaaatkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegag
siaaatgfvkk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >8aexH (H:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexH (H:)
tkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaat
gfvkk

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >8aexI (I:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexI (I:)
gvvaaatkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegag
siaaatgfvkk

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >8aexJ (J:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records): (download) 
    >8aexJ (J:)
tkegvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaat
gfvkk