PDB entry 7z6l

View 7z6l on RCSB PDB site
Description: Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Class: ligase
Keywords: bromodomain, PROTAC complex, E3 ligase, LIGASE
Deposited on 2022-03-12, released 2022-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-09-07, with a file datestamp of 2022-09-02.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Probable global transcription activator SNF2L2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMARCA2, BAF190B, BRM, SNF2A, SNF2L2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51531 (2-122)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7z6la_
  • Chain 'B':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P40337 (2-161)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d7z6lb_
  • Chain 'C':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7z6lc1, d7z6lc2
  • Chain 'D':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7z6ld_
  • Heterogens: IEI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7z6lA (A:)
smaeklspnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvd
fkkikerirnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiak
eee

    Sequence, based on observed residues (ATOM records): (download) 
    >7z6lA (A:)
pnppkltkqmnaiidtvinykdssgrqlsevfiqlpsrkelpeyyelirkpvdfkkiker
irnhkyrslgdlekdvmllchnaqtfnlegsqiyedsivlqsvfksarqkiak

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7z6lB (B:)
gsmeagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihs
yrghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvk
penyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records): (download) 
    >7z6lB (B:)
pvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlfr
dagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrldi
vrslyedledhpnvqkdlerltqeriahq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7z6lC (C:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

    Sequence, based on observed residues (ATOM records): (download) 
    >7z6lC (C:)
mmyvklissdghefivkrehaltsgtikamlsgpnetnevnfreipshvlskvcmyftyk
vrytnssteipefpiapeialellmaanfldc

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7z6lD (D:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk