PDB entry 7xo0

View 7xo0 on RCSB PDB site
Description: Minor polymorph inalpha-synuclein fibril seeded by cerebrospinal fluid from a mid-to-late stage (mid-PD-1) Parkinson's disease patient
Class: protein fibril
Keywords: amyloid fibril, PROTEIN FIBRIL
Deposited on 2022-04-30, released 2022-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-11-30, with a file datestamp of 2022-11-25.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0a_
  • Chain 'B':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0b_
  • Chain 'C':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0c_
  • Chain 'D':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0d_
  • Chain 'E':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0e_
  • Chain 'F':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7xo0f_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7xo0A (A:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0A (A:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7xo0B (B:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0B (B:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >7xo0C (C:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0C (C:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7xo0D (D:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0D (D:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >7xo0E (E:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0E (E:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >7xo0F (F:)
    mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvatvaektk
    eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
    dneayempseegyqdyepea
    

    Sequence, based on observed residues (ATOM records): (download)
    >7xo0F (F:)
    gvlyvgsktkegvvhgvatvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfv
    kk