PDB entry 7uv5

View 7uv5 on RCSB PDB site
Description: The crystal structure of Papain-Like Protease of SARS CoV-2, C111S/D286N mutant, in complex with a Lys48-linked di-ubiquitin
Class: hydrolase
Keywords: covid-19, coronavirus, SARS, CoV-2, papain-like protease, ubiquitin, IDP51000, IDP52003, Center for Structural Genomics of Infectious Diseases, CSGID, HYDROLASE
Deposited on 2022-04-29, released 2022-05-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-05-11, with a file datestamp of 2022-05-06.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Papain-like protease nsp3
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC1 (3-317)
      • expression tag (0-2)
      • engineered mutation (113)
      • engineered mutation (288)
    Domains in SCOPe 2.08: d7uv5a1, d7uv5a2
  • Chain 'B':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7uv5b_
  • Chain 'C':
    Compound: Ubiquitin
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0CG47 (0-75)
      • engineered mutation (47)
    Domains in SCOPe 2.08: d7uv5c_
  • Heterogens: ZN, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7uv5A (A:)
snaevrtikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyv
lpnddtlrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnnsylatal
ltlqqielkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhan
ldsckrvlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqq
espfvmmsappaqyelkhgtftcaseytgnyqcghykhitsketlycingalltksseyk
gpitdvfykensytttik

    Sequence, based on observed residues (ATOM records): (download) 
    >7uv5A (A:)
tikvfttvdninlhtqvvdmsmtygqqfgptyldgadvtkikphnshegktfyvlpnddt
lrveafeyyhttdpsflgrymsalnhtkkwkypqvngltsikwadnnsylatalltlqqi
elkfnppalqdayyrarageaanfcalilaycnktvgelgdvretmsylfqhanldsckr
vlnvvcktcgqqqttlkgveavmymgtlsyeqfkkgvqipctcgkqatkylvqqespfvm
msappaqyelkhgtftcaseytgnyqcghykhitsketlycingalltksseykgpitdv
fykensytttik

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7uv5B (B:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7uv5C (C:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagrqledgrtlsdyn
iqkestlhlvlrlrgg

    Sequence, based on observed residues (ATOM records): (download) 
    >7uv5C (C:)
mqtltgkvepienvkakgippdqqrlifagrqltlhlvlrl