SCOPe 2.08: Structural Classification of Proteins

PDB entry 7tl0

View 7tl0 on RCSB PDB site
Description: Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2
Class: viral protein/immune system
Keywords: neutralizing antibody, fusion protein, metapneumovirus, site 0, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2022-01-17, released 2022-09-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-09-14, with a file datestamp of 2022-09-09.
Experiment type: EM
Resolution: 3.06 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Fusion glycoprotein F0
Species: Human metapneumovirus [TaxId:162145]
Database cross-references and differences (RAF-indexed):
- Uniprot H6X1Z0 (0-489)
  - engineered mutation (99-100)
  - engineered mutation (109)
  - engineered mutation (126)
  - engineered mutation (139)
  - engineered mutation (146)
  - engineered mutation (152)
  - engineered mutation (184)
  - engineered mutation (218)
  - engineered mutation (230)
  - engineered mutation (321)
  - engineered mutation (364)
  - engineered mutation (452)
  - engineered mutation (462)
  - expression tag (490-550)
Chain 'B':
Compound: Fusion glycoprotein F0
Species: Human metapneumovirus [TaxId:162145]
Database cross-references and differences (RAF-indexed):
- Uniprot H6X1Z0 (0-489)
  - engineered mutation (99-100)
  - engineered mutation (109)
  - engineered mutation (126)
  - engineered mutation (139)
  - engineered mutation (146)
  - engineered mutation (152)
  - engineered mutation (184)
  - engineered mutation (218)
  - engineered mutation (230)
  - engineered mutation (321)
  - engineered mutation (364)
  - engineered mutation (452)
  - engineered mutation (462)
  - expression tag (490-550)
Chain 'C':
Compound: Fusion glycoprotein F0
Species: Human metapneumovirus [TaxId:162145]
Database cross-references and differences (RAF-indexed):
- Uniprot H6X1Z0 (0-489)
  - engineered mutation (99-100)
  - engineered mutation (109)
  - engineered mutation (126)
  - engineered mutation (139)
  - engineered mutation (146)
  - engineered mutation (152)
  - engineered mutation (184)
  - engineered mutation (218)
  - engineered mutation (230)
  - engineered mutation (321)
  - engineered mutation (364)
  - engineered mutation (452)
  - engineered mutation (462)
  - expression tag (490-550)
Chain 'D':
Compound: SAN32-2 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-223)
Domains in SCOPe 2.08: d7tl0d_
Chain 'E':
Compound: SAN32-2 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-213)
Domains in SCOPe 2.08: d7tl0e_
Chain 'F':
Compound: SAN32-2 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-223)
Domains in SCOPe 2.08: d7tl0f_
Chain 'G':
Compound: SAN32-2 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-213)
Domains in SCOPe 2.08: d7tl0g_
Chain 'H':
Compound: SAN32-2 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-223)
Domains in SCOPe 2.08: d7tl0h_
Chain 'I':
Compound: SAN32-2 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-213)
Domains in SCOPe 2.08: d7tl0i_
Chain 'J':
Compound: MPE8 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-227)
Domains in SCOPe 2.08: d7tl0j_
Chain 'K':
Compound: MPE8 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-215)
Domains in SCOPe 2.08: d7tl0k_
Chain 'L':
Compound: MPE8 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-227)
Domains in SCOPe 2.08: d7tl0l_
Chain 'M':
Compound: MPE8 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-215)
Domains in SCOPe 2.08: d7tl0m_
Chain 'N':
Compound: MPE8 Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-227)
Domains in SCOPe 2.08: d7tl0n_
Chain 'O':
Compound: MPE8 Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 7TL0 (0-215)
Domains in SCOPe 2.08: d7tl0o_
Heterogens: NAG

PDB Chain Sequences:

Chain 'A':
No sequence available.
Chain 'B':
No sequence available.
Chain 'C':
No sequence available.

Chain 'D':
Sequence, based on SEQRES records: (download)

>7tl0D (D:)
evqlvqsgaevkkpgeslrisckssgytfttywitwvrqmpgkglewmgridpsdsytdy
spsfkghvtisvdksintaylqwgslkssdtaifycarqassgkiyfdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd