PDB entry 7t9k

View 7t9k on RCSB PDB site
Description: Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2
Class: viral protein
Keywords: SARS-CoV-2, glycoprotein, fusion protein, viral protein, ACE2
Deposited on 2021-12-19, released 2021-12-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-12-29, with a file datestamp of 2021-12-24.
Experiment type: EM
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1204)
      • conflict (66)
      • conflict (92)
      • conflict (139)
      • insertion (204)
      • insertion (204)
      • conflict (204)
      • conflict (204)
      • conflict (204)
      • conflict (335)
      • conflict (367)
      • conflict (369)
      • conflict (371)
      • conflict (413)
      • conflict (436)
      • conflict (442)
      • conflict (473-474)
      • conflict (480)
      • conflict (489)
      • conflict (492)
      • conflict (494)
      • conflict (497)
      • conflict (501)
      • conflict (543)
      • conflict (610)
      • conflict (651)
      • conflict (675)
      • conflict (677-679)
      • conflict (681)
      • conflict (760)
      • conflict (792)
      • conflict (813)
      • conflict (852)
      • conflict (888)
      • conflict (895)
      • conflict (938)
      • conflict (950)
      • conflict (965)
      • conflict (977)
      • conflict (982-983)
      • expression tag (1205-1284)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1204)
      • conflict (66)
      • conflict (92)
      • conflict (139)
      • insertion (204)
      • insertion (204)
      • conflict (204)
      • conflict (204)
      • conflict (204)
      • conflict (335)
      • conflict (367)
      • conflict (369)
      • conflict (371)
      • conflict (413)
      • conflict (436)
      • conflict (442)
      • conflict (473-474)
      • conflict (480)
      • conflict (489)
      • conflict (492)
      • conflict (494)
      • conflict (497)
      • conflict (501)
      • conflict (543)
      • conflict (610)
      • conflict (651)
      • conflict (675)
      • conflict (677-679)
      • conflict (681)
      • conflict (760)
      • conflict (792)
      • conflict (813)
      • conflict (852)
      • conflict (888)
      • conflict (895)
      • conflict (938)
      • conflict (950)
      • conflict (965)
      • conflict (977)
      • conflict (982-983)
      • expression tag (1205-1284)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (0-1204)
      • conflict (66)
      • conflict (92)
      • conflict (139)
      • insertion (204)
      • insertion (204)
      • conflict (204)
      • conflict (204)
      • conflict (204)
      • conflict (335)
      • conflict (367)
      • conflict (369)
      • conflict (371)
      • conflict (413)
      • conflict (436)
      • conflict (442)
      • conflict (473-474)
      • conflict (480)
      • conflict (489)
      • conflict (492)
      • conflict (494)
      • conflict (497)
      • conflict (501)
      • conflict (543)
      • conflict (610)
      • conflict (651)
      • conflict (675)
      • conflict (677-679)
      • conflict (681)
      • conflict (760)
      • conflict (792)
      • conflict (813)
      • conflict (852)
      • conflict (888)
      • conflict (895)
      • conflict (938)
      • conflict (950)
      • conflict (965)
      • conflict (977)
      • conflict (982-983)
      • expression tag (1205-1284)
  • Chain 'D':
    Compound: Processed angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BYF1 (0-597)
      • expression tag (598-605)
    Domains in SCOPe 2.08: d7t9kd_
  • Chain 'E':
    Compound: Processed angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BYF1 (0-597)
      • expression tag (598-605)
    Domains in SCOPe 2.08: d7t9ke_
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7t9kD (D:)
qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqs
tlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdn
pqeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhye
dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyis
pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs
vglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemg
hiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqednetein
fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety
cdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnm
lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhh
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7t9kD (D:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspy

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7t9kE (E:)
qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqs
tlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdn
pqeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhye
dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyis
pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs
vglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemg
hiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqednetein
fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety
cdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnm
lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhh
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7t9kE (E:)
stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspy