PDB entry 7t2x

View 7t2x on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 2-chloro-4-((4-hydroxybenzyl)amino)-5-phenylthieno[2,3-d]pyrimidin-6-ol and GRIP Peptide
Class: transcription
Keywords: Estrogen Receptor, Hormone Agonist, Alpha Helical Bundle, Transcription
Deposited on 2021-12-06, released 2022-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-06-22, with a file datestamp of 2022-06-17.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (3-260)
      • initiating methionine (0)
      • expression tag (1-2)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d7t2xa_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372 (3-260)
      • initiating methionine (0)
      • expression tag (1-2)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d7t2xb_
  • Chain 'C':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, BHLHE75, SRC2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, BHLHE75, SRC2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EMY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7t2xA (A:)
mdpmikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladre
lvhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrn
qgkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekd
hihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknv
vplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7t2xA (A:)
ltadqmvsalldaeppilyseasmmglltnladrelvhminwakrvpgfvdltlhdqvhl
lecawleilmiglvwrsmehpgkllfapnllldrnqgmveifdmllatssrfrmmnlqge
efvclksiillnsgvytleekdhihrvldkitdtlihlmakagltlqqqhqrlaqlllil
shirhmsnkgmehlysmklsdlllemldah

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7t2xB (B:)
mdpmikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladre
lvhminwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrn
qgkcvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekd
hihrvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknv
vplsdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >7t2xB (B:)
alsltadqmvsalldaeppilysetrpfseasmmglltnladrelvhminwakrvpgfvd
ltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmll
atssrfrmmnlqgeefvclksiillnsgvytfdhihrvldkitdtlihlmakagltlqqq
hqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldah

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.