PDB entry 7t0d
View 7t0d on RCSB PDB site
Description: Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k
Class: Transferase/Inhibitor
Keywords: Inhibitor, Protein prenylyltransferase, Antifungal, TRANSFERASE, TRANSFERASE-Inhibitor complex
Deposited on
2021-11-29, released
2022-11-09
The last revision prior to the SCOPe 2.08 freeze date was dated
2022-11-09, with a file datestamp of
2022-11-04.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: N/A
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Species: Cryptococcus neoformans var. grubii H99 [TaxId:235443]
Gene: CNAG_02229
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d7t0da_ - Chain 'B':
Compound: Protein farnesyltransferase subunit beta
Species: Cryptococcus neoformans var. grubii H99 [TaxId:235443]
Gene: CNAG_05740
Database cross-references and differences (RAF-indexed):
- Heterogens: XO7, EDO, SO4, 3FX, ZN, FPP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7t0dA (A:)
mgsshhhhhhsqdlmvtstyipmsqrrswadvkpimqddgpnpvvpimyseeykdamdyf
raiaakeekseralelteiivrmnpahytvwqyrfslltslnksledelrlmnefavqnl
ksyqvwhhrlllldrispqdpvseieyihgsllpdpknyhtwaylhwlyshfstlgrise
aqwgseldwcnemlrvdgrnnsawgwrwylrvsrpgaetssrslqdeliyilksihliph
nvsawnylrgflkhfslplvpilpailpytasklnpdietveafgfpmpsdplpedtplp
vplaleyladsfieqnrvddaakvfeklsseydqmragywefrrrecae
Sequence, based on observed residues (ATOM records): (download)
>7t0dA (A:)
tyipmsqrrswadvkpimqddgpnpvvpimyseeykdamdyfraiaakeekseralelte
iivrmnpahytvwqyrfslltslnksledelrlmnefavqnlksyqvwhhrlllldrisp
qdpvseieyihgsllpdpknyhtwaylhwlyshfstlgriseaqwgseldwcnemlrvdg
rnnsawgwrwylrvsrpgaetssrslqdeliyilksihliphnvsawnylrgflkhfslp
lvpilpailpytafgfpmpsdplpedtplpvplaleyladsfieqnrvddaakvfeklss
eydqmragywefrrreca
- Chain 'B':
No sequence available.