PDB entry 7so3

View 7so3 on RCSB PDB site
Description: Crystal Structure of HIV-1 Reverse Transcriptase K103N/Y181C Variant in Complex with (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6-(3-morpholinopropoxy)-1,3,5-triazin-2-yl)amino)benzonitrile (JLJ564)
Class: hydrolase, transferase/viral protein
Keywords: POLYMERASE, TRANSFERASE, HYDROLASE, RNASEH, transferase-viral protein complex
Deposited on 2021-10-29, released 2022-03-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-03-16, with a file datestamp of 2022-03-11.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (2-556)
      • expression tag (0-1)
      • engineered mutation (104)
      • conflict (173-174)
      • engineered mutation (182)
      • conflict (281)
    Domains in SCOPe 2.08: d7so3a1, d7so3a2, d7so3a3
  • Chain 'B':
    Compound: p51 RT
    Species: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) [TaxId:11678]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03366 (0-427)
      • conflict (279)
    Domains in SCOPe 2.08: d7so3b_
  • Heterogens: 9W3, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7so3A (A:)
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsv
pldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdi
vicqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdk
wtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkaltevipltee
aelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmr
gahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvn
tpplvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqkte
lqaiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpa
hkgiggneqvdklvsag

    Sequence, based on observed residues (ATOM records): (download) 
    >7so3A (A:)
mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpynt
pvfaikwrklvdfrelnkrtqdfwegiphpaglkknksvtvldvgdayfsvpldedfrky
taftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdivicqymddl
yvgsdleigqhrtkieelrqhllrwglttppflwmgyelhpdkwtvqpivlpekdswtvn
diqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvh
gvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqki
ttesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepiv
gaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevni
vtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7so3B (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyq

    Sequence, based on observed residues (ATOM records): (download) 
    >7so3B (B:)
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwiphpaglkkkksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddlyv
gsdleigqhrtkieelrqhllrwyelhpdkwtvqpivlpekdswtvndiqklvgklnwas
qiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliae
iqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpk
fklpiqketwetwwteywqatwipewefvntpplvklwyq