PDB entry 7sem

View 7sem on RCSB PDB site
Description: Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins
Class: VIRAL PROTEIN/Immune System
Keywords: human metapneumovirus, fusion protein, VIRAL PROTEIN, VIRAL PROTEIN-Immune System complex
Deposited on 2021-09-30, released 2022-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-02-16, with a file datestamp of 2022-02-11.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: MPE8 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7SEM (0-227)
    Domains in SCOPe 2.08: d7semb_
  • Chain 'C':
    Compound: MPE8 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7SEM (0-215)
    Domains in SCOPe 2.08: d7semc_
  • Chain 'F':
    Compound: Fusion glycoprotein F0
    Species: Human metapneumovirus [TaxId:162145]
    Database cross-references and differences (RAF-indexed):
    • Uniprot H6X1Z0 (0-489)
      • conflict (99-100)
      • conflict (126)
      • conflict (152)
      • conflict (184)
      • conflict (364)
      • conflict (367)
      • conflict (462)
      • expression tag (490-550)
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7semB (B:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisasssysdy
adsakgrftisrdnaktslflqmnslraedtaiyfcararatgyssitpyfdiwgqgtlv
tvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpav
lqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscd

    Sequence, based on observed residues (ATOM records): (download) 
    >7semB (B:)
evqlvesggglvkpggslrlscaasgftfssysmnwvrqapgkglewvssisasssysdy
adsakgrftisrdnaktslflqmnslraedtaiyfcararatgyssitpyfdiwgqgtlv
tvssastkgpsvfplapsalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtyicnvnhkpsntkvdkkvepk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7semC (C:)
qsvvtqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapklliydnnnrpsgv
pdrfsasksgtsaslaitglqaedeadyycqsydrslsgvfgtgtkvtvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaass
ylsltpeqwkshksyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7semC (C:)
svvtqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapklliydnnnrpsgvp
drfsasksgtsaslaitglqaedeadyycqsydrslsgvfgtgtkvtvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkagvetttpskqsnnkyaassylsltpeq
wkshksyscqvthegstvektvap

  • Chain 'F':
    No sequence available.