PDB entry 7rwf

View 7rwf on RCSB PDB site
Description: Crystal structure of CDK2 in complex with TW8672
Class: cell cycle
Keywords: Serine/threonine-protein kinase DNA repair Meiosis allosteric inhibitor drug development, CELL CYCLE
Deposited on 2021-08-19, released 2022-08-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-08-24, with a file datestamp of 2022-08-19.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2, CDKN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • expression tag (0)
    Domains in SCOPe 2.08: d7rwfa1, d7rwfa2
  • Heterogens: 7TW, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7rwfA (A:)
fmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl