PDB entry 7rb7

View 7rb7 on RCSB PDB site
Description: Room temperature structure of hAChE in complex with substrate analog 4K-TMA and MMB4 oxime
Class: hydrolase
Keywords: acetylcholine esterase, serine hydrolase, tetrahedral intermediate, oxime reactivator, HYDROLASE
Deposited on 2021-07-05, released 2021-09-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-09-22, with a file datestamp of 2021-09-17.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22303 (3-549)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb7a_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22303 (3-549)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7rb7b_
  • Heterogens: 3VI, NWA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7rb7A (A:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb7A (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7rb7B (B:)
gplegredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpws
gvvdattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvw
iygggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqr
lalqwvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwa
tvgmgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrf
sfvpvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisra
eflagvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagr
laaqgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlm
rywanfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflp
kllsatdtld

    Sequence, based on observed residues (ATOM records): (download) 
    >7rb7B (B:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvv
dgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagv
rvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqga
rvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanf
artgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat