PDB entry 7r6w

View 7r6w on RCSB PDB site
Description: SARS-CoV-2 spike receptor-binding domain (RBD) in complex with S2X35 Fab and S309 Fab
Class: viral protein/immune system
Keywords: COVID-19, SARS-CoV-2, neutralizing monoclonal antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2021-06-23, released 2021-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 1.83 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heavy chain of Fab domain of monoclonal antibody S309
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6W (0-229)
  • Chain 'B':
    Compound: Light chain of Fab domain of monoclonal antibody S309
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6W (0-213)
    Domains in SCOPe 2.08: d7r6wb_
  • Chain 'H':
    Compound: Heavy Chain of Fab domain of monoclonal antibody S2X35
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6W (0-230)
    Domains in SCOPe 2.08: d7r6wh_
  • Chain 'L':
    Compound: Light Chain of Fab domain of monoclonal antibody S2X35
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7R6W (0-218)
    Domains in SCOPe 2.08: d7r6wl1, d7r6wl2
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (4-207)
      • expression tag (0-3)
      • expression tag (208-215)
    Domains in SCOPe 2.08: d7r6wr_
  • Heterogens: SO4, GOL, CL, POL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7r6wB (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6wB (B:)
eivltqspgtlslspgeratlscrasqtvsstslawyqqkpgqaprlliygassratgip
drfsgsgsgtdftltisrlepedfavyycqqhdtsltfgggtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7r6wH (H:)
qvqlvqsgaevkkpgasvkvsckasgytftnygiswvrqapgqglewmgwisaykgntny
aqklqgrvtmttdtststaymelrslrsddtavyycarpdyqvlgydfwigyygmdvwgq
gttvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6wH (H:)
qvqlvqsgaevkkpgasvkvsckasgytftnygiswvrqapgqglewmgwisaykgntny
aqklqgrvtmttdtststaymelrslrsddtavyycarpdyqvlgydfwigyygmdvwgq
gttvivssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7r6wL (L:)
qsvltqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapklliygntnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgsevvfgggtkltvlgqpkaap
svtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6wL (L:)
svltqppsvsgapgqrvtisctgsssnigagydvhwyqqlpgtapklliygntnrpsgvp
drfsgsksgtsaslaitglqaedeadyycqsydsslsgsevvfgggtkltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvapt

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7r6wR (R:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7r6wR (R:)
tnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcf
tnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynyl
yrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvv
lsfellhapatvcgp