PDB entry 7r1u

View 7r1u on RCSB PDB site
Description: Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the WZ16 inhibitor
Class: viral protein
Keywords: methyltransferase, nsp10, nsp16, inhibitor, VIRAL PROTEIN
Deposited on 2022-02-03, released 2022-06-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-06-29, with a file datestamp of 2022-06-24.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2'-O-methyltransferase NSP16
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-298)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7r1ua_
  • Chain 'B':
    Compound: non-structural protein 10
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: rep, 1a-1b
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTD1 (1-122)
      • initiating methionine (0)
    Domains in SCOPe 2.08: d7r1ub_
  • Heterogens: 4IK, GTA, MES, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7r1uA (A:)
    mssqawqpgvampnlykmqrmllekcdlqnygdsatlpkgimmnvakytqlcqylntltl
    avpynmrvihfgagsdkgvapgtavlrqwlptgtllvdsdlndfvsdadstligdcatvh
    tankwdliisdmydpktknvtkendskegfftyicgfiqqklalggsvaikitehswnad
    lyklmghfawwtafvtnvnassseafligcnylgkpreqidgyvmhanyifwrntnpiql
    ssyslfdmskfplklrgtavmslkegqindmilsllskgrliirennrvvissdvlvnn
    

    Sequence, based on observed residues (ATOM records): (download)
    >7r1uA (A:)
    ssqawqpgvampnlykmqrmllekcdlqnygdsatlpkgimmnvakytqlcqylntltla
    vpynmrvihfgagsdkgvapgtavlrqwlptgtllvdsdlndfvsdadstligdcatvht
    ankwdliisdmydpktknvtkendskegfftyicgfiqqklalggsvaikitehswnadl
    yklmghfawwtafvtnvnassseafligcnylgkpreqidgyvmhanyifwrntnpiqls
    syslfdmskfplklrgtavmslkegqindmilsllskgrliirennrvvissdvlvn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7r1uB (B:)
    mnstvlsfcafavdaakaykdylasggqpitncvkmlcthtgtgqaitvtpeanmdqesf
    ggascclycrchidhpnpkgfcdlkgkyvqipttcandpvgftlkntvctvcgmwkgygc
    scd
    

    Sequence, based on observed residues (ATOM records): (download)
    >7r1uB (B:)
    afavdaakaykdylasggqpitncvkmlcthtgtgqaitvtpeanmdqesfggascclyc
    rchidhpnpkgfcdlkgkyvqipttcandpvgftlkntvctvcgmwkgygcsc