PDB entry 7q29

View 7q29 on RCSB PDB site
Description: Crystal structure of Angiotensin-1 converting enzyme C-domain in complex with dual ACE/NEP inhibitor AD013
Class: hydrolase
Keywords: Angiotensin-1 converting enzyme, Dual inhibitor, NEP, Metalloprotease, HYDROLASE
Deposited on 2021-10-23, released 2022-02-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-02-16, with a file datestamp of 2022-02-11.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: angiotensin-converting enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE, DCP, DCP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P12821 (0-596)
      • engineered mutation (27)
      • engineered mutation (53)
      • engineered mutation (118)
      • engineered mutation (300)
      • engineered mutation (549)
    Domains in SCOPe 2.08: d7q29a_
  • Heterogens: 8JV, NAG, BO3, IMD, PEG, 1PE, EDO, ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7q29A (A:)
lvtdeaeaskfveeydrtsqvvwneyaganwnyntnittetskillqknmqiaqhtlkyg
tqarkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpqg
sclqlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvda
gdswrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllg
nmwaqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefw
qksmlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykd
lpvalreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkia
fipfsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhips
svpyiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpe
amqlitgqpqmsasamlsyfkplldwlrtenelhgeklgwpqynwtpnsarsegplp

    Sequence, based on observed residues (ATOM records): (download) 
    >7q29A (A:)
deaeaskfveeydrtsqvvwneyaganwnyntnittetskillqknmqiaqhtlkygtqa
rkfdvnqlqnttikriikkvqdleraalpaqeleeynkilldmettysvatvchpqgscl
qlepdltnvmatsrkyedllwawegwrdkagrailqfypkyvelinqaarlngyvdagds
wrsmyetpsleqdlerlfqelqplylnlhayvrralhrhygaqhinlegpipahllgnmw
aqtwsniydlvvpfpsapsmdtteamlkqgwtprrmfkeaddfftslgllpvppefwqks
mlekptdgrevvchasawdfyngkdfrikqcttvnledlvvahhemghiqyfmqykdlpv
alreganpgfheaigdvlalsvstpkhlhslnllsseggsdehdinflmkmaldkiafip
fsylvdqwrwrvfdgsitkenynqewwslrlkyqglcppvprtqgdfdpgakfhipssvp
yiryfvsfiiqfqfhealcqaaghtgplhkcdiyqskeagqrlatamklgfsrpwpeamq
litgqpqmsasamlsyfkplldwlrtenelhgeklgwp