PDB entry 7puq

View 7puq on RCSB PDB site
Description: CARM1 in complex with EML982
Class: transcription
Keywords: protein arginine n-methyltransferase, prmt4, carm1, inhibitor, transcription
Deposited on 2021-09-30, released 2022-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-05-11, with a file datestamp of 2022-05-06.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVG6 (3-359)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7puqa_
  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVG6 (3-359)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7puqb_
  • Chain 'C':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVG6 (3-359)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7puqc_
  • Chain 'D':
    Compound: histone-arginine methyltransferase carm1
    Species: Mus musculus [TaxId:10090]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WVG6 (3-359)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d7puqd_
  • Heterogens: 867, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7puqA (A:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp

    Sequence, based on observed residues (ATOM records): (download) 
    >7puqA (A:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffryt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7puqB (B:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp

    Sequence, based on observed residues (ATOM records): (download) 
    >7puqB (B:)
rsvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgc
gsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdi
iisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfw
yqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieip
fkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdt
lsgtclliankrqsydisivaqvdqtgskssnlldlknpffry

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7puqC (C:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp

    Sequence, based on observed residues (ATOM records): (download) 
    >7puqC (C:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffryt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7puqD (D:)
ghmghtlersvfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkd
kivldvgcgsgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveev
slpeqvdiiisepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlyme
qftkanfwyqpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakeg
dlhrieipfkfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsp
lfakagdtlsgtclliankrqsydisivaqvdqtgskssnlldlknpffrytgttpsppp

    Sequence, based on observed residues (ATOM records): (download) 
    >7puqD (D:)
svfserteessavqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcg
sgilsffaaqagarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdii
isepmgymlfnermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwy
qpsfhgvdlsalrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipf
kfhmlhsglvhglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtl
sgtclliankrqsydisivaqvdqtgskssnlldlknpffry