PDB entry 7ouv

View 7ouv on RCSB PDB site
Description: Crystal structure of human filamin C domains 14-15 cardiovascular disease causing mutation S1624L
Class: structural protein
Keywords: Ig-like, mechanosensing, muscle protein, heart, STRUCTURAL PROTEIN
Deposited on 2021-06-13, released 2022-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-06-22, with a file datestamp of 2022-06-17.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isoform 2 of Filamin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: FLNC, ABPL, FLN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14315 (2-204)
      • expression tag (0-1)
      • engineered mutation (92)
    Domains in SCOPe 2.08: d7ouva1, d7ouva2, d7ouva3
  • Chain 'B':
    Compound: Isoform 2 of Filamin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: FLNC, ABPL, FLN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14315 (2-204)
      • expression tag (0-1)
      • engineered mutation (92)
    Domains in SCOPe 2.08: d7ouvb1, d7ouvb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7ouvA (A:)
gplpahdaskvrasgpglnasgipaslpveftidardageglltvqildpegkpkkanir
dngdgtytvsylpdmsgrytitikyggdeipylpfrihalptgdaskclvtvsigghglg
aclgpriqigqetvitvdakaagegkvtctvstpdgaeldvdvvenhdgtfdiyytapep
gkyvitirfggehipnspfhvlate

    Sequence, based on observed residues (ATOM records): (download) 
    >7ouvA (A:)
plpahdaskvrasgpglnasgipaslpveftidardageglltvqildpegkpkkanird
ngdgtytvsylpdmsgrytitikyggdeipylpfrihalptgdaskclvtvsigghglga
clgpriqigqetvitvdakaagegkvtctvstpdgaeldvdvvenhdgtfdiyytapepg
kyvitirfggehipnspfhvlate

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ouvB (B:)
gplpahdaskvrasgpglnasgipaslpveftidardageglltvqildpegkpkkanir
dngdgtytvsylpdmsgrytitikyggdeipylpfrihalptgdaskclvtvsigghglg
aclgpriqigqetvitvdakaagegkvtctvstpdgaeldvdvvenhdgtfdiyytapep
gkyvitirfggehipnspfhvlate

    Sequence, based on observed residues (ATOM records): (download) 
    >7ouvB (B:)
pahdaskvrasgpglnasgipaslpveftidardageglltvqildpegkpkkanirdng
dgtytvsylpdmsgrytitikyggdeipylpfrihalptgdaskclvtvsigghglgacl
gpriqigqetvitvdakaagegkvtctvstpdgaeldvdvvenhdgtfdiyytapepgky
vitirfggehipnspfhvlate