PDB entry 7o4r

View 7o4r on RCSB PDB site
Description: Structure of Mycobacterium tuberculosis beta-oxidation trifunctional enzyme with Coenzyme A bound at the thiolase active sites and additional binding site (CoA(HAD/KAT))
Class: oxidoreductase
Keywords: trifunctional enzyme, fatty acid beta oxidation, mycobacterium tuberculosis, OXIDOREDUCTASE
Deposited on 2021-04-07, released 2021-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-09-22, with a file datestamp of 2021-09-17.
Experiment type: XRAY
Resolution: 2.79 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Gene: fadB, Rv0860
    Database cross-references and differences (RAF-indexed):
    • Uniprot O53872 (16-735)
      • initiating methionine (0)
      • expression tag (1-15)
  • Chain 'B':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Gene: fadB, Rv0860
    Database cross-references and differences (RAF-indexed):
    • Uniprot O53872 (16-735)
      • initiating methionine (0)
      • expression tag (1-15)
  • Chain 'C':
    Compound: Putative acyltransferase Rv0859
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadA, Rv0859
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7o4rc1, d7o4rc2
  • Chain 'D':
    Compound: Putative acyltransferase Rv0859
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: fadA, Rv0859
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7o4rd1, d7o4rd2
  • Heterogens: COA, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7o4rC (C:)
mseeafiyeairtprgkqkngslhevkplslvvglidelrkrhpdldenlisdvilgcvs
pvgdqggdiaraavlasgmpvtsggvqlnrfcasgleavntaaqkvrsgwddlvlaggve
smsrvpmgsdggamgldpatnydvmfvpqsigadliatiegfsredvdayalrsqqkaae
awsggyfaksvvpvrdqngllildhdehmrpdttkeglaklkpafeglaalggfddvalq
kyhwvekinhvhtggnssgivdgaalvmigsaaagklqgltprarivatatsgadpviml
tgptpatrkvldragltvddidlfelneafasvvlkfqkdlnipdeklnvnggaiamghp
lgatgamilgtmvdelerrnarralitlcigggmgvatiierv

    Sequence, based on observed residues (ATOM records): (download) 
    >7o4rC (C:)
seeafiyeairtprgkqkngslhevkplslvvglidelrkrhpdldenlisdvilgcvsp
vgdqggdiaraavlasgmpvtsggvqlnrfcasgleavntaaqkvrsgwddlvlaggves
msrvpmgsdggamgldpatnydvmfvpqsigadliatiegfsredvdayalrsqqkaaea
wsggyfaksvvpvrdqngllildhdehmrpdttkeglaklkpafeglaalggfddvalqk
yhwvekinhvhtggnssgivdgaalvmigsaaagklqgltprarivatatsgadpvimlt
gptpatrkvldragltvddidlfelneafasvvlkfqkdlnipdeklnvnggaiamghpl
gatgamilgtmvdelerrnarralitlcigggmgvatiierv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7o4rD (D:)
mseeafiyeairtprgkqkngslhevkplslvvglidelrkrhpdldenlisdvilgcvs
pvgdqggdiaraavlasgmpvtsggvqlnrfcasgleavntaaqkvrsgwddlvlaggve
smsrvpmgsdggamgldpatnydvmfvpqsigadliatiegfsredvdayalrsqqkaae
awsggyfaksvvpvrdqngllildhdehmrpdttkeglaklkpafeglaalggfddvalq
kyhwvekinhvhtggnssgivdgaalvmigsaaagklqgltprarivatatsgadpviml
tgptpatrkvldragltvddidlfelneafasvvlkfqkdlnipdeklnvnggaiamghp
lgatgamilgtmvdelerrnarralitlcigggmgvatiierv

    Sequence, based on observed residues (ATOM records): (download) 
    >7o4rD (D:)
seeafiyeairtprgkqkngslhevkplslvvglidelrkrhpdldenlisdvilgcvsp
vgdqggdiaraavlasgmpvtsggvqlnrfcasgleavntaaqkvrsgwddlvlaggves
msrvpmgsdggamgldpatnydvmfvpqsigadliatiegfsredvdayalrsqqkaaea
wsggyfaksvvpvrdqngllildhdehmrpdttkeglaklkpafeglaalggfddvalqk
yhwvekinhvhtggnssgivdgaalvmigsaaagklqgltprarivatatsgadptpatr
kvldragltvddidlfelneafasvvlkfqkdlnipdeklnvnggaiamghplgatgami
lgtmvdelerrnarralitlcgmgvatiierv