PDB entry 7nxk

View 7nxk on RCSB PDB site
Description: Crystal structure of human Cdk12/Cyclin K in complex with the inhibitor BSJ-01-175
Class: transcription
Keywords: CDK12, Cyclin K, CCNK, BSJ-01-175, kinase, TRANSCRIPTION
Deposited on 2021-03-18, released 2021-05-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK12, CRK7, CRKRS, KIAA0904
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7nxka_
  • Chain 'B':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNK, CPR4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7nxkb1, d7nxkb2
  • Chain 'C':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK12, CRK7, CRKRS, KIAA0904
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7nxkc_
  • Chain 'D':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene: CCNK, CPR4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7nxkd1, d7nxkd2
  • Heterogens: UUB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7nxkA (A:)
gqtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrqsgvvveeppps

    Sequence, based on observed residues (ATOM records): (download) 
    >7nxkA (A:)
tesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaire
ikilrqlihrsvvnmkeivtdkqdkkdkgafylvfeymdhdlmgllesglvhfsedhiks
fmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvit
lwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpa
vwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsd
flkdvelskmappdlphwqdch

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7nxkB (B:)
gmkenkensspsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifd
vgtrlglhydtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiikt
arsllndvqfgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiq
klvqmawtfvndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfv
qdvpvdvledichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >7nxkB (B:)
tkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfh
rfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkee
vmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlsl
qwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlys
qgkqqm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7nxkC (C:)
gqtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrqsgvvveeppps

    Sequence, based on observed residues (ATOM records): (download) 
    >7nxkC (C:)
sdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireik
ilrqlihrsvvnmkeivtdkgafylvfeymdhdlmgllesglvhfsedhiksfmkqlmeg
leychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvitlwyrppel
llgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavwpdvikl
pyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdflkdvels
kmappdlphwqdch

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7nxkD (D:)
gmkenkensspsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifd
vgtrlglhydtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiikt
arsllndvqfgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiq
klvqmawtfvndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfv
qdvpvdvledichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >7nxkD (D:)
kpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhr
fymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeev
mvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslq
wepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlysq
g