PDB entry 7nvx

View 7nvx on RCSB PDB site
Description: tfiih in a post-translocated state (with adp-bef3)
Deposited on 2021-03-16, released 2021-05-05
The last revision was dated 2021-06-16, with a file datestamp of 2021-06-11.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '0':
    Compound: TFIIH basal transcription factor complex helicase XPD subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: ERCC2, XPD, XPDC
    Database cross-references and differences (RAF-indexed):
  • Chain '1':
    Compound: General transcription factor IIH subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2H1, BTF2
    Database cross-references and differences (RAF-indexed):
  • Chain '2':
    Compound: General transcription factor IIH subunit 4
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2H4
    Database cross-references and differences (RAF-indexed):
  • Chain '3':
    Compound: cdk-activating kinase assembly factor mat1
    Species: Homo sapiens [TaxId:9606]
    Gene: MNAT1, CAP35, MAT1, RNF66
    Database cross-references and differences (RAF-indexed):
  • Chain '4':
    Compound: General transcription factor IIH subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2H3
    Database cross-references and differences (RAF-indexed):
  • Chain '5':
    Compound: General transcription factor IIH subunit 5
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2H5, C6orf175, TTDA
    Database cross-references and differences (RAF-indexed):
  • Chain '6':
    Compound: General transcription factor IIH subunit 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2H2, BTF2P44
    Database cross-references and differences (RAF-indexed):
  • Chain '7':
    Compound: General transcription and DNA repair factor IIH helicase subunit XPB
    Species: Homo sapiens [TaxId:9606]
    Gene: ERCC3, XPB, XPBC
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: non-template DNA
    Species: Human mastadenovirus C, synthetic [TaxId:129951]
  • Chain 'T':
    Compound: Template DNA
    Species: Human mastadenovirus C, synthetic [TaxId:129951]
  • Chain 'W':
    Compound: General transcription factor IIE subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: GTF2E1, TF2E1
    Database cross-references and differences (RAF-indexed):
  • Chain 'Y':
    Compound: Unassigned peptide, likely XPB
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NVX (0-7)
  • Chain 'Z':
    Compound: Unassigned peptide, likely TFIIE-beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NVX (0-15)
  • Heterogens: SF4, ZN, ADP, MG, BEF

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain '0':
    Sequence, based on SEQRES records:
    >7nvx0 (0:)
    mklnvdgllvyfpydyiypeqfsymrelkrtldakghgvlempsgtgktvsllalimayq
    rayplevtkliycsrtvpeiekvieelrkllnfyekqegeklpflglalssrknlcihpe
    vtplrfgkdvdgkchsltasyvraqyqhdtslphcrfyeefdahgrevplpagiynlddl
    kalgrrqgwcpyflarysilhanvvvysyhylldpkiadlvskelarkavvvfdeahnid
    nvcidsmsvnltrrtldrcqgnletlqktvlriketdeqrlrdeyrrlveglreasaare
    tdahlanpvlpdevlqeavpgsirtaehflgflrrlleyvkwrlrvqhvvqesppaflsg
    laqrvciqrkplrfcaerlrsllhtleitdladfspltllanfatlvstyakgftiiiep
    fddrtptianpilhfscmdaslaikpvferfqsviitsgtlspldiypkildfhpvtmat
    ftmtlarvclcpmiigrgndqvaisskfetrediavirnygnlllemsavvpdgivafft
    syqymestvaswyeqgileniqrnkllfietqdgaetsvalekyqeacengrgaillsva
    rgkvsegidfvhhygravimfgvpyvytqsrilkarleylrdqfqirendfltfdamrha
    aqcvgrairgktdyglmvfadkrfargdkrgklprwiqehltdanlnltvdegvqvakyf
    lrqmaqpfhredqlglsllsleqleseetlkrieqiaqql
    

    Sequence, based on observed residues (ATOM records):
    >7nvx0 (0:)
    mklnvdgllvyfpydyiypeqfsymrelkrtldakghgvlempsgtgktvsllalimayq
    rayplevtkliycsrtvpeiekvieelrkllnfyekqegeklpflglalssrknlcihpe
    vtplrfgkdvdgkchsltasyvraqyqhdtslphcrfyeefdahgrevplpagiynlddl
    kalgrrqgwcpyflarysilhanvvvysyhylldpkiadlvskelarkavvvfdeahnid
    nvcidsmsvnltrrtldrcqgnletlqktvlriketdeqrlrdeyrrlveganpvlpdev
    lqeavpgsirtaehflgflrrlleyvkwrlrvqhvvqesppaflsglaqrvciqrkplrf
    caerlrsllhtleitdladfspltllanfatlvstyakgftiiiepfddrtptianpilh
    fscmdaslaikpvferfqsviitsgtlspldiypkildfhpvtmatftmtlarvclcpmi
    igrgndqvaisskfetrediavirnygnlllemsavvpdgivafftsyqymestvaswye
    qgileniqrnkllfietqdgaetsvalekyqeacengrgaillsvargkvsegidfvhhy
    gravimfgvpyvytqsrilkarleylrdqfqirendfltfdamrhaaqcvgrairgktdy
    glmvfadkrfargdkrgklprwiqehltdanlnltvdegvqvakyflrqmaqpf
    

  • Chain '1':
    Sequence, based on SEQRES records:
    >7nvx1 (1:)
    matsseevllivkkvrqkkqdgalylmaeriawapegkdrftishmyadikcqkispegk
    akiqlqlvlhagdttnfhfsnestavkerdavkdllqqllpkfkrkankeleeknrmlqe
    dpvlfqlykdlvvsqvisaeefwanrlnvnatdssstsnhkqdvgisaafladvrpqtdg
    cnglrynltsdiiesifrtypavkmkyaenvphnmtekefwtrffqshyfhrdrlntgsk
    dlfaecakidekglktmvslgvknplldltaledkpldegygissvpsasnsksikensn
    aaiikrfnhhsamvlaaglrkqeaqneqtsepsnmdgnsgdadcfqpavkraklqesiey
    edlgknnsvktialnlkksdryyhgptpiqslqyatsqdiinsfqsirqemeaytpkltq
    vlsssaasstitalspggalmqggtqqainqmvpndiqselkhlyvavgellrhfwscfp
    vntpfleekvvkmksnlerfqvtklcpfqekirrqylstnlvshieemlqtaynklhtwq
    srrlmkkt
    

    Sequence, based on observed residues (ATOM records):
    >7nvx1 (1:)
    ankeleeknrmlqedpvlfqlykdlvvsqvisaeefwanrsdiiesifrtypavkmkyae
    nvphnmtekefwtrffqensnaaiikrfnhhsamvlaaglrkialnlkksdryyhgptpi
    tsqdiinsfqsirqemeaytpkltqvlsssaasstitalspggalmqgqmvpndiqselk
    hlyvavgellrhfwscfpvntpfleekvvkmksnlerfqvtklcpfqekirrqylstnlv
    shieemlqtaynklhtwqsrrlmkk
    

  • Chain '2':
    Sequence, based on SEQRES records:
    >7nvx2 (2:)
    mestpsrglnrvhlqcrnlqeflgglspgvldrlyghpatclavfrelpslaknwvmrml
    fleqplpqaavalwvkkefskaqeestgllsglriwhtqllpgglqglilnpifrqnlri
    allgggkawsddtsqlgpdkhardvpsldkyaeerwevvlhfmvgspsaavsqdlaqlls
    qaglmkstepgeppcitsagfqfllldtpaqlwyfmlqylqtaqsrgmdlveilsflfql
    sfstlgkdysvegmsdsllnflqhlrefglvfqrkrksrryyptrlainlssgvsgaggt
    vhqpgfivvetnyrlyayteselqialialfsemlyrfpnmvvaqvtresvqqaiasgit
    aqqiihflrtrahpvmlkqtpvlpptitdqirlwelerdrlrftegvlynqflsqvdfel
    llaharelgvlvfensakrlmvvtpaghsdvkrfwkrqkhss
    

    Sequence, based on observed residues (ATOM records):
    >7nvx2 (2:)
    nlqeflgglspgvldrlyghpatclavfrelpslaknwvmrmlfleqplpqaavalwvkk
    efskaqeestgllsglriwhtqllilnpifrqnlriallggvpsldkyaeerwevvlhfm
    vgspsaavsqdlaqllsqaglmkstepgeppcitsagfqfllldtpaqlwyfmlqylqta
    qsrgmdlveilsflfqlsfsdsllnflqhlrefglvfqrkrksrryyptrlainqpgfiv
    vetnyrlyayteselqialialfsemlyrfpnmvvaqvtresvqqaiasgitaqqiihfl
    rtrahpvmlkqtpvlpptitdqirlwelerdrlrftegvlynqflsqvdfelllaharel
    gvlvfensakrlmvvtpaghsdvkrfwkrq
    

  • Chain '3':
    Sequence, based on SEQRES records:
    >7nvx3 (3:)
    mddqgcprckttkyrnpslklmvnvcghtlcescvdllfvrgagncpecgtplrksnfrv
    qlfedptvdkeveirkkvlkiynkreedfpslreyndfleeveeivfnltnnvdldntkk
    kmeiyqkenkdviqknklkltreqeeleealeverqeneqrrlfiqkeeqlqqilkrknk
    qafldelessdlpvalllaqhkdrstqlemqlekpkpvkpvtfstgikmgqhislapihk
    leealyeyqplqietygphvpelemlgrlgylnhvraaspqdlaggytsslachralqda
    fsglfwqps
    

    Sequence, based on observed residues (ATOM records):
    >7nvx3 (3:)
    mddqgcprckttkyrnpslklmvnvcghtlcescvdllfvrgagncpecgtplrksnfrv
    qlfedptvdkeveirkkvlkiynkreedfpslreyndfleeveeivfnltnnvdldntkk
    kmeiyqkenkdviqknklkltreqeelee
    

  • Chain '4':
    Sequence, based on SEQRES records:
    >7nvx4 (4:)
    mvsdedelnllvivvdanpiwwgkqalkesqftlskcidavmvlgnshlfmnrsnklavi
    ashiqesrflypgkngrlgdffgdpgnppefnpsgskdgkyelltsaneviveeikdlmt
    ksdikgqhtetllagslakalcyihrmnkevkdnqemksrilvikaaedsalqymnfmnv
    ifaaqkqnilidacvldsdsgllqqacditgglylkvpqmpsllqyllwvflpdqdqrsq
    lilpppvhvdyraacfchrnlieigyvcsvclsifcnfspicttcetafkislppvlkak
    kkklkvsa
    

    Sequence, based on observed residues (ATOM records):
    >7nvx4 (4:)
    lnllvivvdanpiwwgkqalkesqftlskcidavmvlgnshlfmnrsnklaviashiqes
    rflypgskdgkyelltsaneviveeikdlmtksdikgqhtetllagslakalcyihrmnk
    evkdnqemksrilvikaaedsalqymnfmnvifaaqkqnilidacvldsdsgllqqacdi
    tgglylkvpqmpsllqyllwvflpdqdqrsqlilpppvhvdyraacfchrnlieigyvcs
    vclsifcnfspicttcetafkis
    

  • Chain '5':
    Sequence, based on SEQRES records:
    >7nvx5 (5:)
    mvnvlkgvliecdpamkqfllyldesnalgkkfiiqdiddthvfviaelvnvlqervgel
    mdqnafsltqk
    

    Sequence, based on observed residues (ATOM records):
    >7nvx5 (5:)
    nvlkgvliecdpamkqfllyldesnalgkkfiiqdiddthvfviaelvnvlqervgelmd
    qnafsl
    

  • Chain '6':
    Sequence, based on SEQRES records:
    >7nvx6 (6:)
    mdeepertkrweggyertweilkedesgslkatiedilfkakrkrvfehhgqvrlgmmrh
    lyvvvdgsrtmedqdlkpnrltctlklleyfveeyfdqnpisqigiivtkskraekltel
    sgnprkhitslkkavdmtchgepslynslsiamqtlkhmpghtsrevliifsslttcdps
    niydliktlkaakirvsviglsaevrvctvlaretggtyhvildeshykellthhvsppp
    assssecslirmgfpqhtiaslsdqdakpsfsmahldgntepgltlggyfcpqcrakyce
    lpveckicgltlvsaphlarsyhhlfpldafqeipleeyngerfcygcqgelkdqhvyvc
    avcqnvfcvdcdvfvhdslhccpgcihkipapsgv
    

    Sequence, based on observed residues (ATOM records):
    >7nvx6 (6:)
    vrlgmmrhlyvvvdgsrtmedqdlkpnrltctlklleyfveeyfdqnpisqigiivtksk
    raekltelsgnprkhitslkkavdmtchgepslynslsiamqtlkhmpghtsrevliifs
    slttcdpsniydliktlkaakirvsviglsaevrvctvlaretggtyhvildeshykell
    thhvspppassssecslirmgfpqhtiaslsdqdakpsfsmaepgltlggyfcpqcraky
    celpveckicgltlvsaphlarsyhhlfpldafqeipleeyngerfcygcqgelkdqhvy
    vcavcqnvfcvdcdvfvhdslhccpgcih
    

  • Chain '7':
    Sequence, based on SEQRES records:
    >7nvx7 (7:)
    mgkrdradrdkkksrkrhyedeeddeedapgndpqeavpsaagkqvdesgtkvdeygakd
    yrlqmplkddhtsrplwvapdghifleafspvykyaqdflvaiaepvcrpthvheyklta
    yslyaavsvglqtsditeylrklsktgvpdgimqfiklctvsygkvklvlkhnryfvesc
    hpdviqhllqdpvirecrlrnsegeatelitetftsksaisktaessggpstsrvtdpqg
    ksdipmdlfdfyeqmdkdeeeeeetqtvsfevkqemieelqkrcihleypllaeydfrnd
    svnpdinidlkptavlrpyqekslrkmfgngrarsgvivlpcgagkslvgvtaactvrkr
    clvlgnsavsveqwkaqfkmwstiddsqicrftsdakdkpigcsvaistysmlghttkrs
    weaervmewlktqewglmildevhtipakmfrrvltivqahcklgltatlvreddkivdl
    nfligpklyeanwmelqnngyiakvqcaevwcpmspefyreyvaiktkkrillytmnpnk
    fracqflikfherrndkiivfadnvfalkeyairlnkpyiygptsqgermqilqnfkhnp
    kintifiskvgdtsfdlpeanvliqisshggsrrqeaqrlgrvlrakkgmvaeeynaffy
    slvsqdtqemaystkrqrflvdqgysfkvitklagmeeedlafstkeeqqqllqkvlaat
    dldaeeevvagefgsrssqasrrfgtmssmsgaddtvymeyhssrskapskhvhplfkrf
    rk
    

    Sequence, based on observed residues (ATOM records):
    >7nvx7 (7:)
    tkvdeygakdyrlqmplkddhtsrplwvapdghifleafspvykyaqdflvaiaepvcrp
    thvheykltayslyaavsvglqtsditeylrklsktgvpdgimqfiklctvsygkvklvl
    khnryfveschpdviqhllqdpvirecrlrqtvsfevkqemieelqkrcihleypllaey
    dfrndsvnpdinidlkptavlrpyqekslrkmfgngrarsgvivlpcgagkslvgvtaac
    tvrkrclvlgnsavsveqwkaqfkmwstiddsqicrftsdakdkpigcsvaistysmlgh
    ttkrsweaervmewlktqewglmildevhtipakmfrrvltivqahcklgltatlvredd
    kivdlnfligpklyeanwmelqnngyiakvqcaevwcpmspefyreyvaiktkkrillyt
    mnpnkfracqflikfherrndkiivfadnvfalkeyairlnkpyiygptsqgermqilqn
    fkhnpkintifiskvgdtsfdlpeanvliqisshggsrrqeaqrlgrvlrakkgmvaeey
    naffyslvsqdtqemaystkrqrflvdqgysfkvitklagmeeedlafstkeeqqqllqk
    vlaat
    

  • Chain 'N':
    No sequence available.

  • Chain 'T':
    No sequence available.

  • Chain 'W':
    Sequence, based on SEQRES records:
    >7nvxW (W:)
    madpdvltevpaalkrlakyvirgfygiehalaldilirnscvkeedmlellkfdrkqlr
    svlnnlkgdkfikcrmrvetaadgkttrhnyyfinyrtlvnvvkykldhmrrrietderd
    stnrasfkcpvcsstftdleanqlfdpmtgtfrctfchteveedesampkkdartllarf
    neqiepiyallretedvnlayeilepepteipalkqskdhaattagaaslagghhreawa
    tkgpsyedlytqnvvinmddqedlhraslegksakerpiwlrestvqgaygsedmkeggi
    dmdafqereeghagpddneevmrallihekktssamagsvgaaapvtaangddsesetse
    sdddspprpaavavhkreedeeeddefeevaddpivmvagrpfsysevsqrpelvaqmtp
    eekeayiamgqrmfedlfe
    

    Sequence, based on observed residues (ATOM records):
    >7nvxW (W:)
    akerpiwlrestvqg
    

  • Chain 'Y':
    Sequence; same for both SEQRES and ATOM records:
    >7nvxY (Y:)
    xxxxxxxx
    

  • Chain 'Z':
    Sequence; same for both SEQRES and ATOM records:
    >7nvxZ (Z:)
    xxxxxxxxxxxxxxxx