PDB entry 7ntu

View 7ntu on RCSB PDB site
Description: x-ray structure of the complex between human alpha thrombin and two duplex/quadruplex aptamers: nu172 and hd22_27mer
Deposited on 2021-03-10, released 2021-04-28
The last revision was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Prothrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Prothrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Prothrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Prothrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: nu172
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'F':
    Compound: HD22_27mer
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'G':
    Compound: nu172
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'I':
    Compound: HD22_27mer
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: 0G6, NAG, NA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ntuA (A:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records):
    >7ntuA (A:)
eadcglrplfekksledkterellesyi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ntuB (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records):
    >7ntuB (B:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkk
wiqkvidqf

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7ntuC (C:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records):
    >7ntuC (C:)
eadcglrplfekksledkterellesyi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7ntuD (D:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records):
    >7ntuD (D:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlkegqpsvlqvvnlpiverpvckdstriritdnmfca
gykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkk
wiqkvidqf

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'I':
    No sequence available.