PDB entry 7nfd

View 7nfd on RCSB PDB site
Description: structure of mitoxantrone-bound abcg2
Deposited on 2021-02-06, released 2021-04-21
The last revision was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: EM
Resolution: 3.51 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: 5D3(Fab) light chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NFD (0-End)
  • Chain 'D':
    Compound: 5D3(Fab) heavy chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NFD
  • Chain 'E':
    Compound: 5D3(Fab) light chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NFD (0-End)
  • Chain 'F':
    Compound: 5D3(Fab) heavy chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NFD
  • Heterogens: MIX

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7nfdA (A:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >7nfdA (A:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgyttsfchqlrwvskrsfknl
lgnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelf
vvekklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffv
mmftlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswl
qyfsiprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwk
nhvalacmivifltiaylkllflkky

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7nfdB (B:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >7nfdB (B:)
avlsfhnicyrvkeilsningimkpglnailgptgggksslldvlaarkdpsglsgdvli
ngaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqel
gldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldepttgldsstanavllll
krmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceayn
npadffldiingdlieklaeiyvnssfyketkaelhqlsgyttsfchqlrwvskrsfknl
lgnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvlfflttnqcfssvsavelf
vvekklfiheyisgyyrvssyflgkllsdllpmrmlpsiiftcivyfmlglkpkadaffv
mmftlmmvaysassmalaiaagqsvvsvatllmticfvfmmifsgllvnlttiaswlswl
qyfsiprygftalqhneflgqnfcpglnatgnnpcnyatctgeeylvkqgidlspwglwk
nhvalacmivifltiaylkllflkky

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7nfdC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >7nfdC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7nfdD (D:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records):
    >7nfdD (D:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7nfdE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >7nfdE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7nfdF (F:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records):
    >7nfdF (F:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss