PDB entry 7neq

View 7neq on RCSB PDB site
Description: Structure of tariquidar-bound ABCG2
Class: membrane protein
Keywords: ABCG2, tariquidar, substrate, ABC transporter, anticancer drugs, cavity 1, cryo-EM, MEMBRANE PROTEIN
Deposited on 2021-02-04, released 2021-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: EM
Resolution: 3.12 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: 5D3(Fab) light chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NEQ (0-End)
    Domains in SCOPe 2.08: d7neqc1
  • Chain 'D':
    Compound: 5D3(Fab) heavy chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NEQ
    Domains in SCOPe 2.08: d7neqd1, d7neqd2
  • Chain 'E':
    Compound: 5D3(Fab) light chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NEQ (0-End)
    Domains in SCOPe 2.08: d7neqe1
  • Chain 'F':
    Compound: 5D3(Fab) heavy chain variable domain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7NEQ
    Domains in SCOPe 2.08: d7neqf1, d7neqf2
  • Heterogens: R1H, NAG, U9N, CLR, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7neqC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >7neqC (C:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7neqD (D:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records): (download) 
    >7neqD (D:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7neqE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleirradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >7neqE (E:)
divltqspssfsvslgdrvtisckasgyilnrlawyqqkpgnaprllisgatsletgfps
rfsgtgsgkdytlsisslqtedvgtyycqqywstpwtfgggtkleir

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7neqF (F:)
qvqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggtty
npslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvssa
kttppsvyplapvcgdtsgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records): (download) 
    >7neqF (F:)
vqlqesgpglvkpsqslsltctvtgfsitsdyawnwirqfpgkklewmgyinfdggttyn
pslrgrisitrdtsknqfflqlrsvtpedtatyycatfygakgtldywgqgtsvtvss