PDB entry 7nbi

View 7nbi on RCSB PDB site
Description: Crystal structure of a monomeric FLT3 Ligand variant
Class: de novo protein
Keywords: FLT3 Ligand, Engineered cytokine, monomeric FLT3 ligand, DE NOVO PROTEIN
Deposited on 2021-01-26, released 2021-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fms-related tyrosine kinase 3 ligand
    Species: Homo sapiens [TaxId:9606]
    Gene: FLT3LG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49771 (Start-137)
      • engineered mutation (30)
    Domains in SCOPe 2.08: d7nbia_
  • Chain 'B':
    Compound: Fms-related tyrosine kinase 3 ligand
    Species: Homo sapiens [TaxId:9606]
    Gene: FLT3LG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49771 (4-137)
      • expression tag (0-3)
      • engineered mutation (30)
    Domains in SCOPe 2.08: d7nbib1, d7nbib2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7nbiA (A:)
gshmtqdcsfqhspissdfavkirelsdyldqdypvtvasnlqdeelcgglwrlvlaqrw
merlktvagskmqgllervnteihfvtkcafqpppsclrfvqtnisrllqetseqlvalk
pwitrqnfsrclelqcqp

    Sequence, based on observed residues (ATOM records): (download) 
    >7nbiA (A:)
csfqhspissdfavkirelsdyldqdypvtvasnlqdeelcgglwrlvlaqrwmerlktv
agskmqgllervnteihfvtkcafqpppsclrfvqtnisrllqetseqlvalkpwitrqn
fsrclelqcqp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7nbiB (B:)
gshmtqdcsfqhspissdfavkirelsdyldqdypvtvasnlqdeelcgglwrlvlaqrw
merlktvagskmqgllervnteihfvtkcafqpppsclrfvqtnisrllqetseqlvalk
pwitrqnfsrclelqcqp