PDB entry 7mjm

View 7mjm on RCSB PDB site
Description: Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain
Class: viral protein
Keywords: SARS-CoV-2, glycoprotein, fusion protein, viral protein, ACE2
Deposited on 2021-04-20, released 2021-05-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: EM
Resolution: 2.83 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (500)
      • conflict (816)
      • conflict (891)
      • conflict (898)
      • conflict (941)
      • conflict (985-986)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (500)
      • conflict (816)
      • conflict (891)
      • conflict (898)
      • conflict (941)
      • conflict (985-986)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (500)
      • conflict (816)
      • conflict (891)
      • conflict (898)
      • conflict (941)
      • conflict (985-986)
  • Chain 'D':
    Compound: Processed angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7mjmd_
  • Chain 'E':
    Compound: Processed angiotensin-converting enzyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ACE2, UNQ868/PRO1885
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7mjme_
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7mjmD (D:)
    qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqs
    tlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdn
    pqeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhye
    dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyis
    pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs
    vglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemg
    hiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqednetein
    fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety
    cdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnm
    lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhh
    hhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >7mjmD (D:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
    qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
    ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
    igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
    glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
    iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
    llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
    dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
    rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspya
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >7mjmE (E:)
    qstieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqs
    tlaqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdn
    pqeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhye
    dygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyis
    pigclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvs
    vglpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemg
    hiqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqednetein
    fllkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdety
    cdpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnm
    lrlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspyadhh
    hhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >7mjmE (E:)
    stieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
    laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
    qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
    ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
    igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
    glpnmtqgfwensmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
    iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
    llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
    dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
    rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspya