PDB entry 7mhc

View 7mhc on RCSB PDB site
Description: Structure of human STING in complex with MK-1454
Class: immune system
Keywords: sting, receptor, ligand complex, agonist, closed conformation, immune system
Deposited on 2021-04-15, released 2022-04-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-04-06, with a file datestamp of 2022-04-01.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Stimulator of interferon genes protein
    Species: Homo sapiens [TaxId:9606]
    Gene: STING1, ERIS, MITA, TMEM173
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q86WV6 (0-187)
      • engineered mutation (76)
      • engineered mutation (78)
      • engineered mutation (139)
    Domains in SCOPe 2.08: d7mhca_
  • Heterogens: ZEV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7mhcA (A:)
nvahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqqtadragikdrvysnsiyellengqragtcvleyatplqtlfamsq
ysqagfsredrleqaklfcqtlediladapesqnncrliayqepaddssfslsqevlrhl
rqeekeev

    Sequence, based on observed residues (ATOM records): (download) 
    >7mhcA (A:)
nvahglawsyyigylrlilpelqarirtynqhynnllrgavsqrlyillpldcgvpdnls
madpnirfldklpqqtadragikdrvysnsiyellengqragtcvleyatplqtlfamsq
ysqagfsredrleqaklfcqtlediladapesqnncrliayqepsfslsqevlrhlrqe