PDB entry 7mes

View 7mes on RCSB PDB site
Description: Structure of ALDH4A1 complexed with trans-4-Hydroxy-D-proline
Class: oxidoreductase
Keywords: aldehyde dehydrogenase, Rossmann fold, nucleotide binding, acting on aldehyde or oxo group of donors, NAD or NADP as acceptor, mitochondria, OXIDOREDUCTASE
Deposited on 2021-04-07, released 2021-06-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: N/A
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (21-562)
      • expression tag (0-20)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d7mesa_
  • Chain 'B':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (21-562)
      • expression tag (0-20)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d7mesb_
  • Heterogens: NAD, UY7, PG4, PEG, 1PE, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7mesA (A:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >7mesA (A:)
vanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdiqyqlspfnhahkv
akfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgprraevlaktmvgq
gktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyrglegfvaaispfn
ftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppniiqfvpadgptfgd
tvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggknfhfvhssadvds
vvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvgdpaedfgtffsav
idakafarikkwleharsspslsilaggqcnesvgyyvepciieskdpqepimkeeifgp
vltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlrnaagnfyindkst
gsvvgqqpfggarasgtndkpggphyilrwtspqvikethkpl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7mesB (B:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >7mesB (B:)
slkvanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdiqyqlspfnha
hkvakfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgprraevlaktm
vgqgktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyrglegfvaais
pfnftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppniiqfvpadgpt
fgdtvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggknfhfvhssad
vdsvvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvgdpaedfgtff
savidakafarikkwleharsspslsilaggqcnesvgyyvepciieskdpqepimkeei
fgpvltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlrnaagnfyind
kstgsvvgqqpfggarasgtndkpggphyilrwtspqvikethkplg