PDB entry 7mby

View 7mby on RCSB PDB site
Description: human cholecystokinin 1 receptor (cck1r) gq chimera (mgsqi) complex
Deposited on 2021-04-01, released 2021-05-26
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 2.44 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,with certain residues mutated to match Guanine nucleotide-binding protein G(q) subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63096 (8-36)
      • expression tag (0-7)
    • Uniprot P63092 (37-63)
      • engineered mutation (38)
      • engineered mutation (40)
      • conflict (48-49)
      • linker (64-71)
    • Uniprot P63092 (72-252)
      • conflict (117)
      • conflict (120)
      • conflict (130)
      • engineered mutation (201)
      • engineered mutation (204-205)
      • engineered mutation (216)
      • conflict (230)
      • conflict (233)
      • engineered mutation (238)
      • engineered mutation (242-243)
      • engineered mutation (245)
      • engineered mutation (248)
      • engineered mutation (250)
      • engineered mutation (252)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: cholecystokinin-8
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Cholecystokinin receptor type A
    Species: Homo sapiens [TaxId:9606]
    Gene: CCKAR, CCKRA
    Database cross-references and differences (RAF-indexed):
  • Heterogens: TYS, Y01

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7mbyA (A:)
hhhhhhhhgctlsaedkaaverskmidrnlredgekarrtlrllllgadnsgkstivkqm
rilhggsggsggtsgifetkfqvdkvnfhmfdvggqrderrkwiqcfndvtaiifvvdss
dynrlqealndfksiwnnrwlrtisvilflnkqdllaekvlagkskiedyfpefaryttp
edatpepgedprvtrakyfirkefvdistasgdgrhicyphftcavdtenarrifndckd
iilqmnlreynlv

    Sequence, based on observed residues (ATOM records):
    >7mbyA (A:)
aaverskmidrnlredgekarrtlrllllgadnsgkstivkqifetkfqvdkvnfhmfdv
grrkwiqcfndvtaiifvvdssdynrlqealndfksiwnnrwlrtisvilflnkqdllae
kvlaskiedyfpefaryttedprvtrakyfirkefvdistasgdgrhicyphftcavdte
narrifndckdiilqmnlreynlv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7mbyB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >7mbyB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7mbyG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >7mbyG (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >7mbyP (P:)
dymgwmdf

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7mbyR (R:)
dvvdsllvngsnitppcelglenetlfcldqprpskewqpavqillyslifllsvlgntl
vitvlirnkrmrtvtnifllslavsdlmlclfcmpfnlipnllkdfifgsavcktttyfm
gtsvsvstfnlvaislerygaickplqsrvwqtkshalkviaatwclsftimtpypiysn
lvpftknnnqtanmcrfllpndvmqqswhtflllilflipgivmmvayglislelyqgik
feasqkksakerkpsttssgkyedsdgcylqktrpprklelrqlstgsssranrirsnss
aanlmakkrvirmlivivvlfflcwmpifsanawraydtasaerrlsgtpisfilllsyt
sscvnpiiycfmnkrfrlgfmatfpccpnpgppgargevgeeeeggttgaslsrfsyshm
sasvppq

    Sequence, based on observed residues (ATOM records):
    >7mbyR (R:)
ewqpavqillyslifllsvlgntlvitvlirnkrmrtvtnifllslavsdlmlclfcmpf
nlipnllkdfifgsavcktttyfmgtsvsvstfnlvaislerygaickplqsrvwqtksh
alkviaatwclsftimtpypiysnlvpftknnnqtanmcrfllpndvmqqswhtflllil
flipgivmmvayglislelyqlmakkrvirmlivivvlfflcwmpifsanawraydtasa
errlsgtpisfilllsytsscvnpiiycfmnkrfrlgfmatfp