PDB entry 7mbx

View 7mbx on RCSB PDB site
Description: human cholecystokinin 1 receptor (cck1r) gs complex
Deposited on 2021-04-01, released 2021-05-26
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63092 (0-393)
      • conflict (53)
      • conflict (225)
      • conflict (267)
      • conflict (270)
      • conflict (273)
      • conflict (279)
      • conflict (283-284)
      • engineered mutation (365)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: Nanobody35
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7MBX (0-137)
  • Chain 'P':
    Compound: cholecystokinin-8
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'R':
    Compound: Cholecystokinin receptor type A
    Species: Homo sapiens [TaxId:9606]
    Gene: CCKAR, CCKRA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32238 (0-426)
      • expression tag (427-434)
  • Heterogens: TYS, Y01, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7mbxA (A:)
mgclgnsktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkntivkqm
rilhvngfngeggeedpqaarsnsdgekatkvqdiknnlkeaietivaamsnlvppvela
npenqfrvdyilsvmnvpdfdfppefyehakalwedegvracyersneyqlidcaqyfld
kidvikqadyvpsdqdllrcrvltsgifetkfqvdkvnfhmfdvgaqrderrkwiqcfnd
vtaiifvvasssynmvirednqtnrlqaalklfdsiwnnkwlrdtsvilflnkqdllaek
vlagkskiedyfpefaryttpedatpepgedprvtrakyfirdeflristasgdgrhycy
phftcsvdtenirrvfndcrdiiqrmhlrqyell

    Sequence, based on observed residues (ATOM records):
    >7mbxA (A:)
ktedqrneekaqreankkiekqlqkdkqvyrathrllllgagesgkntivkqmrilhtsg
ifetkfqvdkvnfhmfdvgaqrderrkwiqcfndvtaiifvvasssyqtnrlqaalklfd
siwnnkwlrdtsvilflnkqdllaekvlagkskiedyfpefaryttpedatpepgedprv
trakyfirdeflristasgdgrhycyphftcsvdtenirrvfndcrdiiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7mbxB (B:)
mseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >7mbxB (B:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7mbxG (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffcail

    Sequence, based on observed residues (ATOM records):
    >7mbxG (G:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records:
    >7mbxN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvsshhhhhhepea

    Sequence, based on observed residues (ATOM records):
    >7mbxN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >7mbxP (P:)
dymgwmdf

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7mbxR (R:)
dvvdsllvngsnitppcelglenetlfcldqprpskewqpavqillyslifllsvlgntl
vitvlirnkrmrtvtnifllslavsdlmlclfcmpfnlipnllkdfifgsavcktttyfm
gtsvsvstfnlvaislerygaickplqsrvwqtkshalkviaatwclsftimtpypiysn
lvpftknnnqtanmcrfllpndvmqqswhtflllilflipgivmmvayglislelyqgik
feasqkksakerkpsttssgkyedsdgcylqktrpprklelrqlstgsssranrirsnss
aanlmakkrvirmlivivvlfflcwmpifsanawraydtasaerrlsgtpisfilllsyt
sscvnpiiycfmnkrfrlgfmatfpccpnpgppgargevgeeeeggttgaslsrfsyshm
sasvppqhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7mbxR (R:)
ewqpavqillyslifllsvlgntlvitvlirnkrmrtvtnifllslavsdlmlclfcmpf
nlipnllkdfifgsavcktttyfmgtsvsvstfnlvaislerygaickplqsrvwqtksh
alkviaatwclsftimtpypiysnlvpftknnnqtanmcrfllpndvmqqswhtflllil
flipgivmmvayglislelyqgikfesaanlmakkrvirmlivivvlfflcwmpifsana
wraydtasaerrlsgtpisfilllsytsscvnpiiycfmnkrfrlgfmatfp