PDB entry 7m7w

View 7m7w on RCSB PDB site
Description: Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape
Class: viral protein/immune system
Keywords: COVID-19, SARS-CoV-2, neutralizing monoclonal antibody, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2021-03-29, released 2021-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Monoclonal antibody S2X259 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-228)
    Domains in SCOPe 2.08: d7m7wa_
  • Chain 'B':
    Compound: Monoclonal antibody S2X259 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-218)
    Domains in SCOPe 2.08: d7m7wb1, d7m7wb2
  • Chain 'C':
    Compound: Monoclonal antibody S2H97 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-222)
    Domains in SCOPe 2.08: d7m7wc_
  • Chain 'D':
    Compound: Monoclonal antibody S2H97 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-217)
    Domains in SCOPe 2.08: d7m7wd1, d7m7wd2
  • Chain 'E':
    Compound: Monoclonal antibody S2H97 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-222)
    Domains in SCOPe 2.08: d7m7we_
  • Chain 'F':
    Compound: Monoclonal antibody S2H97 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-217)
    Domains in SCOPe 2.08: d7m7wf1, d7m7wf2
  • Chain 'H':
    Compound: Monoclonal antibody S2X259 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-228)
    Domains in SCOPe 2.08: d7m7wh_
  • Chain 'L':
    Compound: Monoclonal antibody S2X259 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M7W (0-218)
    Domains in SCOPe 2.08: d7m7wl1, d7m7wl2
  • Chain 'R':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (4-207)
      • expression tag (0-3)
      • expression tag (208-215)
    Domains in SCOPe 2.08: d7m7wr_
  • Chain 'S':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (4-207)
      • expression tag (0-3)
      • expression tag (208-215)
    Domains in SCOPe 2.08: d7m7ws_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7m7wA (A:)
qvqlvqsgaevkkpgssvkvsckasggifntytiswvrqapgqglewmgriilmsgmany
aqkiqgrvtitadkststaymeltslrsddtavyycargfngnyygwgdddafdiwgqgt
lvtvysastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wA (A:)
vqlvqsgaevkkpgssvkvsckasggifntytiswvrqapgqglewmgriilmsgmanya
qkiqgrvtitadkststaymeltslrsddtavyycargfngnyygwgdddafdiwgqgtl
vtvysastkgpsvfplapsgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7m7wB (B:)
qtvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaap
svtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wB (B:)
tvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgvp
drfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7m7wC (C:)
qvrlvqsgaevkksgeslkisckgsgysftsywigwvrqmpgkglewmgiiypgdsdtry
spsfqgqvtisadksistvylqwsslkasdtamyycarqwshytydyyywgqgtlvtiss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wC (C:)
qvrlvqsgaevkksgeslkisckgsgysftsywigwvrqmpgkglewmgiiypgdsdtry
spsfqgqvtisadksistvylqwsslkasdtamyycarqwshytydyyywgqgtlvtiss
astkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7m7wD (D:)
qsvltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgv
snrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wD (D:)
svltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgvs
nrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7m7wE (E:)
qvrlvqsgaevkksgeslkisckgsgysftsywigwvrqmpgkglewmgiiypgdsdtry
spsfqgqvtisadksistvylqwsslkasdtamyycarqwshytydyyywgqgtlvtiss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wE (E:)
qvrlvqsgaevkksgeslkisckgsgysftsywigwvrqmpgkglewmgiiypgdsdtry
spsfqgqvtisadksistvylqwsslkasdtamyycarqwshytydyyywgqgtlvtiss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepks

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >7m7wF (F:)
qsvltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgv
snrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wF (F:)
svltqpasvsgspgqsitisctgissdvggynsvswyqqhpgkapklmiydvtnrpsgvs
nrfsgsksgntasltisglqaedeadyycssytssstppyvfgtgtkvsvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >7m7wH (H:)
qvqlvqsgaevkkpgssvkvsckasggifntytiswvrqapgqglewmgriilmsgmany
aqkiqgrvtitadkststaymeltslrsddtavyycargfngnyygwgdddafdiwgqgt
lvtvysastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfp
avlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wH (H:)
qlvqsgaevkkpgssvkvsckasggifntytiswvrqapgqglewmgriilmsgmanyaq
kiqgrvtitadkststaymeltslrsddtavyycargfngnyygwgdddafdiwgqgtlv
tvysastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkrvepks

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7m7wL (L:)
qtvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgv
pdrfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaap
svtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wL (L:)
tvltqppsvsgapgqrvtisctgsnsnigagydvhwyqqlpgtapkllicgnsnrpsgvp
drfsgsksgtsaslaitglqaedeadyycqsydsslsgpnwvfgggtkltvlgqpkaaps
vtlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaa
ssylsltpeqwkshrsyscqvthegstvektvapte

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >7m7wR (R:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wR (R:)
itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlc
ftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyny
lyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvv
vlsfellhapatvcgpkk

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >7m7wS (S:)
etgtrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkksthhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7m7wS (S:)
itnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlc
ftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyny
lyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvv
vlsfellhapatvcgpk