PDB entry 7m6g

View 7m6g on RCSB PDB site
Description: structure of the sars-cov-2 s 6p trimer in complex with the human neutralizing antibody fab fragment, bg7-15
Deposited on 2021-03-25, released 2021-05-05
The last revision was dated 2021-06-23, with a file datestamp of 2021-06-18.
Experiment type: EM
Resolution: 3.7 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (816)
      • engineered mutation (891)
      • engineered mutation (898)
      • engineered mutation (941)
      • engineered mutation (985-986)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (816)
      • engineered mutation (891)
      • engineered mutation (898)
      • engineered mutation (941)
      • engineered mutation (985-986)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2
      • engineered mutation (816)
      • engineered mutation (891)
      • engineered mutation (898)
      • engineered mutation (941)
      • engineered mutation (985-986)
  • Chain 'H':
    Compound: BG7-15 Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M6G (0-End)
  • Chain 'L':
    Compound: BG7-15 Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M6G (0-End)
  • Chain 'R':
    Compound: BG7-15 Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M6G (0-End)
  • Chain 'S':
    Compound: BG7-15 Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7M6G (0-End)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7m6gA (A:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrspiedllfnkvtladagfikqygdc
lgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagpalqipfpm
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstpsalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrslevlfqgpghhhhhhhhsaw
shpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7m6gA (A:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhfdnpvlpfndgvyfastnii
rgwifgttldsktqsllivnnatnvvikvcefqfcndpflgefrvyssannctfeyvsqp
flknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllal
hrgaaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnf
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldsynylyrplqsygfqptvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnf
nfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitpg
tntsnqvavlyqdvnctevsnvfqtragcligaehvnnsyecdipigagicavasqsiia
ytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlll
qygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpsk
rspiedllfnkvtlqkfngltvlpplltdemiaqytsallagtitsgwtfgagpalqipf
pmqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstpsalgklqdvvnqnaqa
lntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaei
rasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknftta
paichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvy
dplqpeld

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7m6gB (B:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrspiedllfnkvtladagfikqygdc
lgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagpalqipfpm
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstpsalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrslevlfqgpghhhhhhhhsaw
shpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7m6gB (B:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhnpvlpfndgvyfasteksni
irgwifgttldsktqsllivnnatnvvikvcefqfcndpflsefrvyssannctfeyvsq
pflknlrefvfknidgyfkiyskhtppqgfsaleplvdlpiginitrfqtllaayyvgyl
qprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfp
nitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndl
cftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnyn
ylyrnlkpferdistencyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkks
tnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpc
sfggvsvitpgtntsnqvavlyqdvnctevtgsnvfqtragcligaehvnnsyecdipig
agicavasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmy
icgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfn
fsqilpdpskpskrspiedllfnkvtlqkfngltvlpplltdemiaqytsallagtitsg
wtfgagpalqipfpmqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstpsal
gklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslq
tyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhv
tyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgn
cdvvigivnntvydplqpeld

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7m6gC (C:)
mfvflvllplvssqcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffs
nvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqslliv
nnatnvvikvcefqfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmdle
gkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqt
llalhrsyltpgdsssgwtagaaayyvgylqprtfllkynengtitdavdcaldplsetk
ctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisn
cvadysvlynsasfstfkcygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiad
ynyklpddftgcviawnsnnldskvggnynylyrlfrksnlkpferdisteiyqagstpc
ngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvn
fnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtleilditpcsfggvsvitp
gtntsnqvavlyqdvnctevpvaihadqltptwrvystgsnvfqtragcligaehvnnsy
ecdipigagicasyqtqtnspgsassvasqsiiaytmslgaensvaysnnsiaiptnfti
svtteilpvsmtktsvdctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqe
vfaqvkqiyktppikdfggfnfsqilpdpskpskrspiedllfnkvtladagfikqygdc
lgdiaardlicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagpalqipfpm
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstpsalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqkeidrlnevaknlneslidl
qelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrslevlfqgpghhhhhhhhsaw
shpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7m6gC (C:)
aytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhdnpvlpfndgvyfastniir
gwifgttldsktqsllivnnatnvvikvcefqfcndpffrvyssannctfeyvsqpflkn
lrefvfknidgyfkiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhgaa
ayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvqpt
esivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvs
ptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnlds
kvggnynylyrnlkpferdistencyfplqsygfqptngvgyqpyrvvvlsfellhapat
vcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqtle
ilditpcsfggvsvitpgtntsnqvavlyqdvnctevnvfqtragcligaehvnnsyecd
ipigagicavasqsiiaytmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvd
ctmyicgdstecsnlllqygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdf
ggfnfsqilpdpskpskrspiedllfnkvtlqkfngltvlpplltdemiaqytsallagt
itsgwtfgagpalqipfpmqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsst
psalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrl
qslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvv
flhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntf
vsgncdvvigivnntvydplqpeld

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7m6gH (H:)
qvqlvqsgaevkkpgasvkvsckasgytftsyaiswvrqapgqglewmgwvsayngntny
aqklqgrvtmttdtstntaymelrslrsddtaiyycaipyssvtfdcwgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkt

    Sequence, based on observed residues (ATOM records):
    >7m6gH (H:)
qvqlvqsgaevkkpgasvkvsckasgytftsyaiswvrqapgqglewmgwvsayngntny
aqklqgrvtmttdtstntaymelrslrsddtaiyycaipyssvtfdcwgqgtlvtv

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7m6gL (L:)
eivltqspgtlslspgeratlscrasqsvsgtflawyqqkpgqaprllisgassratgip
drfsgsgsgtdftltisrlepedfavyycqqygssrptfgqgtkleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7m6gL (L:)
eivltqspgtlslspgeratlscrasqsvsgtflawyqqkpgqaprllisgassratgip
drfsgsgsgtdftltisrlepedfavyycqqygssrptfgqgtklei

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7m6gR (R:)
qvqlvqsgaevkkpgasvkvsckasgytftsyaiswvrqapgqglewmgwvsayngntny
aqklqgrvtmttdtstntaymelrslrsddtaiyycaipyssvtfdcwgqgtlvtvssas
tkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgl
yslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkt

    Sequence, based on observed residues (ATOM records):
    >7m6gR (R:)
qvqlvqsgaevkkpgasvkvsckasgytftsyaiswvrqapgqglewmgwvsayngntny
aqklqgrvtmttdtstntaymelrslrsddtaiyycaipyssvtfdcwgqgtlvtv

  • Chain 'S':
    Sequence, based on SEQRES records:
    >7m6gS (S:)
eivltqspgtlslspgeratlscrasqsvsgtflawyqqkpgqaprllisgassratgip
drfsgsgsgtdftltisrlepedfavyycqqygssrptfgqgtkleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >7m6gS (S:)
eivltqspgtlslspgeratlscrasqsvsgtflawyqqkpgqaprllisgassratgip
drfsgsgsgtdftltisrlepedfavyycqqygssrptfgqgtklei