PDB entry 7m3q

View 7m3q on RCSB PDB site
Description: Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
Class: signaling protein/transferase
Keywords: High-affinity, SIGNALING PROTEIN, SIGNALING PROTEIN-TRANSFERASE complex
Deposited on 2021-03-18, released 2021-04-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: E3 ubiquitin-protein ligase SMURF2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMURF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7m3qa_
  • Chain 'B':
    Compound: Ubiquitin variant
    Species: Homo sapiens [TaxId:9606]
    Gene: UBA52, UBCEP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62987 (25-97)
      • initiating methionine (24)
      • variant (25)
      • variant (29)
      • variant (31-32)
      • variant (34)
      • variant (70)
      • variant (85)
      • variant (91)
      • variant (94)
    Domains in SCOPe 2.08: d7m3qb_
  • Heterogens: SO4, NA, CL, DTT, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7m3qA (A:)
gamaprykrdlvqklkilrqelsqqqpqaghcrievsreeifeesyrqvmkmrpkdlwkr
lmikfrgeegldyggvarewlyllshemlnpyyglfqysrddiytlqinpdsavnpehls
yfhfvgrimgmavfhghyidggftlpfykqllgksitlddmelvdpdlhnslvwilendi
tgvldhtfcvehnaygeiiqhelkpngksipvneenkkeyvrlyvnwrflrgieaqflal
qkgfnevipqhllktfdekeleliicglgkidvndwkvntrlkhctpdsnivkwfwkave
ffdeerrarllqfvtgssrvplqgfkalqgaagprlftihqidactnnlpkahtcfnrid
ippyesyeklyeklltaieetcgfave

    Sequence, based on observed residues (ATOM records): (download) 
    >7m3qA (A:)
krdlvqklkilrqelsqqqpqaghcrievsreeifeesyrqvmkmrpkdlwkrlmikfrg
eegldyggvarewlyllshemlnpyyglfqysrddiytlqinpdsavnpehlsyfhfvgr
imgmavfhghyidggftlpfykqllgksitlddmelvdpdlhnslvwilenditgvldht
fcvehnaygeiiqhelkpngksipvneenkkeyvrlyvnwrflrgieaqflalqkgfnev
ipqhllktfdekeleliicglgkidvndwkvntrlkhctpdsnivkwfwkaveffdeerr
arllqfvtgssrvplqgfkalqgaagprlftihqidactnnlpkahtcfnridippyesy
eklyeklltaieet

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7m3qB (B:)
mahhhhhhvtslykkagdykdddkmlifvwtfkgntitlevepsdtienvkakiqdkegi
ppdqqrlifarkqledgrtlsdynilkestlllvrrlr

    Sequence, based on observed residues (ATOM records): (download) 
    >7m3qB (B:)
mlifvwtfkgntitlevepsdtienvkakiqdkegippdqqrlifarkqledrtlsdyni
lkestlllvrrlr