PDB entry 7m3e

View 7m3e on RCSB PDB site
Description: asymmetric activation of the calcium sensing receptor homodimer
Deposited on 2021-03-18, released 2021-06-30
The last revision was dated 2021-07-21, with a file datestamp of 2021-07-16.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Extracellular calcium-sensing receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CASR, GPRC2A, PCAR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41180 (27-901)
      • initiating methionine (0)
      • expression tag (1-26)
  • Chain 'B':
    Compound: Extracellular calcium-sensing receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CASR, GPRC2A, PCAR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41180 (27-901)
      • initiating methionine (0)
      • expression tag (1-26)
  • Heterogens: YP1, NAG, TRP, CA, PO4

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7m3eA (A:)
mktiialsyifclvfadykddddkaaaygpdqraqkkgdiilgglfpihfgvaakdqdlk
srpesvecirynfrgfrwlqamifaieeinsspallpnltlgyrifdtcntvskaleatl
sfvaqnkidslnldefcncsehipstiavvgatgsgvstavanllglfyipqvsyasssr
llsnknqfksflrtipndehqatamadiieyfrwnwvgtiaadddygrpgiekfreeaee
rdicidfselisqysdeeeiqhvveviqnstakvivvfssgpdleplikeivrrnitgki
wlaseawasssliampqyfhvvggtigfalkagqipgfreflkkvhprksvhngfakefw
eetfnchlqegakgplpvdtflrgheesgdrfsnsstafrplctgdenissvetpyidyt
hlrisynvylavysiahalqdiytclpgrglftngscadikkveawqvlkhlrhlnftnn
mgeqvtfdecgdlvgnysiinwhlspedgsivfkevgyynvyakkgerlfineekilwsg
fsrevpfsncsrdclagtrkgiiegeptccfecvecpdgeysdetdasacnkcpddfwsn
enhtsciakeieflswtepfgialtlfavlgifltafvlgvfikfrntpivkatnrelsy
lllfsllccfssslffigepqdwtcrlrqpafgisfvlciscilvktnrvllvfeakipt
sfhrkwwglnlqfllvflctfmqivicviwlytappssyrnqeledeiifitchegslma
lgfligytcllaaicfffafksrklpenfneakfitfsmliffivwisfipayastygkf
vsaveviailaasfgllaciffnkiyiilfkpsrntieevrcstaahafkvaaratlrrs
nv

    Sequence, based on observed residues (ATOM records):
    >7m3eA (A:)
ygpdqraqkkgdiilgglfpihfgvaakdqdlksrpesvecirynfrgfrwlqamifaie
einsspallpnltlgyrifdtcntvskaleatlsfvaqnkidslnldcsehipstiavvg
atgsgvstavanllglfyipqvsyasssrllsnknqfksflrtipndehqatamadiiey
frwnwvgtiaadddygrpgiekfreeaeerdicidfselisqysdeeeiqhvveviqnst
akvivvfssgpdleplikeivrrnitgkiwlaseawasssliampqyfhvvggtigfalk
agqipgfreflkkvhprksvhngfakefweetfnchlqfrplctgdenissvetpyidyt
hlrisynvylavysiahalqdiytclpgrglftngscadikkveawqvlkhlrhlnftnn
mgeqvtfdecgdlvgnysiinwhlspedgsivfkevgyynvyakkgerlfineekilwsg
fsrevpfsncsrdclagtrkgiiegeptccfecvecpdgeysdetdasacnkcpddfwsn
enhtsciakeieflswtepfgialtlfavlgifltafvlgvfikfrntpivkatnrelsy
lllfsllccfssslffigepqdwtcrlrqpafgisfvlciscilvktnrvllvflnlqfl
lvflctfmqivicviwlytappssyrnqeledeiifitchegslmalgfligytcllaai
cfffafksrklpenfneakfitfsmliffivwisfipayastygkfvsaveviailaasf
gllaciffnkiyiilfkpsrntieevrcst

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7m3eB (B:)
mktiialsyifclvfadykddddkaaaygpdqraqkkgdiilgglfpihfgvaakdqdlk
srpesvecirynfrgfrwlqamifaieeinsspallpnltlgyrifdtcntvskaleatl
sfvaqnkidslnldefcncsehipstiavvgatgsgvstavanllglfyipqvsyasssr
llsnknqfksflrtipndehqatamadiieyfrwnwvgtiaadddygrpgiekfreeaee
rdicidfselisqysdeeeiqhvveviqnstakvivvfssgpdleplikeivrrnitgki
wlaseawasssliampqyfhvvggtigfalkagqipgfreflkkvhprksvhngfakefw
eetfnchlqegakgplpvdtflrgheesgdrfsnsstafrplctgdenissvetpyidyt
hlrisynvylavysiahalqdiytclpgrglftngscadikkveawqvlkhlrhlnftnn
mgeqvtfdecgdlvgnysiinwhlspedgsivfkevgyynvyakkgerlfineekilwsg
fsrevpfsncsrdclagtrkgiiegeptccfecvecpdgeysdetdasacnkcpddfwsn
enhtsciakeieflswtepfgialtlfavlgifltafvlgvfikfrntpivkatnrelsy
lllfsllccfssslffigepqdwtcrlrqpafgisfvlciscilvktnrvllvfeakipt
sfhrkwwglnlqfllvflctfmqivicviwlytappssyrnqeledeiifitchegslma
lgfligytcllaaicfffafksrklpenfneakfitfsmliffivwisfipayastygkf
vsaveviailaasfgllaciffnkiyiilfkpsrntieevrcstaahafkvaaratlrrs
nv

    Sequence, based on observed residues (ATOM records):
    >7m3eB (B:)
ygpdqraqkkgdiilgglfpihfgvaakdqdlksrpesvecirynfrgfrwlqamifaie
einsspallpnltlgyrifdtcntvskaleatlsfvaqnkidslnldcsehipstiavvg
atgsgvstavanllglfyipqvsyasssrllsnknqfksflrtipndehqatamadiiey
frwnwvgtiaadddygrpgiekfreeaeerdicidfselisqysdeeeiqhvveviqnst
akvivvfssgpdleplikeivrrnitgkiwlaseawasssliampqyfhvvggtigfalk
agqipgfreflkkvhprksvhngfakefweetfnchlqegfrplctgdenissvetpyid
ythlrisynvylavysiahalqdiytclpgrglftngscadikkveawqvlkhlrhlnft
nnmgeqvtfdecgdlvgnysiinwhlspedgsivfkevgyynvyakkgerlfineekilw
sgfsrevpfsncsrdclagtrkgiiegeptccfecvecpdgeysdetdasacnkcpddfw
snenhtsciakeieflswtepfgialtlfavlgifltafvlgvfikfrntpivkatnrel
sylllfsllccfssslffigepqdwtcrlrqpafgisfvlciscilvktnrvllvflnlq
fllvflctfmqivicviwlytappssyrnqeledeiifitchegslmalgfligytclla
aicfffafksrklpenfneakfitfsmliffivwisfipayastygkfvsaveviailaa
sfgllaciffnkiyiilfkpsrntieevrcst