SCOPe 2.08: Structural Classification of Proteins

PDB entry 7m31

View 7m31 on RCSB PDB site
Description: dihydropyrimidine dehydrogenase (dpd) c671s mutant soaked with thymine and nadph anaerobically
Deposited on 2021-03-18, released 2021-06-09
The last revision was dated 2021-06-23, with a file datestamp of 2021-06-18.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
Species: Sus scrofa [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
  - engineered mutation (670)
Chain 'B':
Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
Species: Sus scrofa [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
  - engineered mutation (670)
Chain 'C':
Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
Species: Sus scrofa [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
  - engineered mutation (670)
Chain 'D':
Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
Species: Sus scrofa [TaxId:9823]
Gene: DPYD
Database cross-references and differences (RAF-indexed):
- Uniprot Q28943
  - conflict (59)
  - engineered mutation (670)
Heterogens: FAD, FMN, NAP, PRO, SF4, TDR, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>7m31A (A:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlssphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records):

>7m31A (A:)
pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
dalelnlssphggmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraake
ggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralp
gfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieel
qgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafpp
lerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcnds
gyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'B':
Sequence, based on SEQRES records:

>7m31B (B:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlssphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records):

>7m31B (B:)
pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
dalelnlssphgmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeg
gadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpg
fpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelq
gwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafppl
erkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsg
yqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglp

Chain 'C':
Sequence, based on SEQRES records:

>7m31C (C:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlssphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records):

>7m31C (C:)
pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
dalelnlssphlacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeggad
gvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpgfpi
latggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelqgwd
gqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafpplerk
pfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqa
iqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

Chain 'D':
Sequence, based on SEQRES records:

>7m31D (D:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlssphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

Sequence, based on observed residues (ATOM records):

>7m31D (D:)
pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
dalelnlssphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiar
aakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttia
ralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylks
ieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqna
afpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymt
cndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpl