PDB entry 7lxl

View 7lxl on RCSB PDB site
Description: Crystal structure of human CYP3A4 bound to the testosterone dimer
Class: oxidoreductase
Keywords: CYP3A4, ligand, testosterone dimer, complex, OXIDOREDUCTASE
Deposited on 2021-03-04, released 2021-04-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-19, with a file datestamp of 2021-05-14.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A4, CYP3A3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7lxla_
  • Heterogens: YNV, HEM

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7lxlA (A:)
aylygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpv
laitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgk
lkemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqd
pfventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrl
edtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyel
athpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdv
eingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprn
cigmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtvs
gahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lxlA (A:)
hshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdp
dmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvp
iiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfvent
kklldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesqkhrvdflqlmid
sqnhkalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavlpnka
pptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsyalhr
dpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirvlqnf
sfkpcketqiplklslggllqpekpvvlkvesr