PDB entry 7lrd

View 7lrd on RCSB PDB site
Description: cryo-em of the slfn12-pde3a complex: consensus subset model
Deposited on 2021-02-16, released 2021-06-09
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 3.22 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Schlafen family member 12
    Species: Homo sapiens [TaxId:9606]
    Gene: SLFN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8IYM2 (5-582)
      • expression tag (0-4)
  • Chain 'B':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-502)
      • expression tag (0)
  • Chain 'C':
    Compound: Schlafen family member 12
    Species: Homo sapiens [TaxId:9606]
    Gene: SLFN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8IYM2 (5-582)
      • expression tag (0-4)
  • Chain 'D':
    Compound: cGMP-inhibited 3',5'-cyclic phosphodiesterase A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE3A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14432 (1-502)
      • expression tag (0)
  • Heterogens: X5M, ZN, MN, MG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lrdA (A:)
ggggsmnisvdletnyaelvldvgrvtlgensrkkmkdcklrkkqnesvsramcallnsg
ggvikaeienedysytkdgigldlensfsnillfvpeyldfmqngnyflifvkswslnts
glrittlssnlykrditsakvmnataaleflkdmkktrgrlylrpellakrpcvdiqeen
nmkalagvffdrteldrkekltftesthveiknfstekllqrikeilpqyvsafantdgg
ylfiglnedkeiigfkaemsdlddlereieksirkmpvhhfcmekkkinysckflgvydk
gslcgyvcalrverfccavfakepdswhvkdnrvmqltrkewiqfmveaepkfsssyeev
isqintslpaphswpllewqrqrhhcpglsgritytpenlcrklflqheglkqliceemd
svrkgslifsrswsvdlglqenhkvlcdallisqdsppvlytfhmvqdeefkgystqtal
tlkqklakiggytkkvcvmtkifylspegmtscqydlrsqviypesyyftrrkyllkalf
kalkrlkslrdqfsfaenlyqiigidcfqkndkkmfkscrrlt

    Sequence, based on observed residues (ATOM records):
    >7lrdA (A:)
nisvdletnyaelvldvgrvtlgensrkkmkdcklrkkqnesvsramcallnsgggvika
eienedysytkdgigldlensfsnillfvpeyldfmqngnyflifvkswslntsglritt
lssnlykrditsakvmnataaleflkdmkktrgrllakrpcvdiqeennmkalagvffdr
teldrkekltftesthveiknfstekllqrikeilpqyvsafantdggylfiglnedkei
igfkaemsdlddlereieksirkmpvhhfcmekkkinysckflgvydkgslcgyvcalrv
erfccavfakepdswhvkdnrvmqltrkewiqfmveaeritytpenlcrklflqheglkq
liceemdsvrkgslifsrswsvdlglqenhkvlcdallisqdsppvlytfhmvqdeefkg
ystqtaltlkqklakiggytkkvcvmtkifylspegmtscqydlrsqviypesyyftrrk
yllkalfkalkrlkslrdqfsfaenlyqiigi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lrdB (B:)
gedeteclreplrkasacstyapetmmfldkpilapeplvmdnldsimeqlntwnfpifd
lvenigrkcgrilsqvsyrlfedmglfeafkipirefmnyfhaleigyrdipyhnrihat
dvlhavwylttqpipglstvindhgstsdsdsdsgfthghmgyvfsktynvtddkygcls
gnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenhhaaaawnlfm
srpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddvgidwtnendr
llvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpispfmdrsapqla
nlqesfishivgplcnsydsaglmpgkwvedsdesgdtddpeeeeeeapapneeetcenn
espkkktfkrrkiycqitqhllqnhkmwkkvieeeqrlagienqsldqtpqshsseqiqa
ikeeeeekgkprgeeiptqkpdq

    Sequence, based on observed residues (ATOM records):
    >7lrdB (B:)
kpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeaf
kipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstvgyvfsktynv
tddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenhh
aaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddvg
idwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpispf
mdrsapqlanlqesfishivgplcnsydsaglmpgkwverkiycqitqhllqnhkmwkkv
ieeeqrlagie

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lrdC (C:)
ggggsmnisvdletnyaelvldvgrvtlgensrkkmkdcklrkkqnesvsramcallnsg
ggvikaeienedysytkdgigldlensfsnillfvpeyldfmqngnyflifvkswslnts
glrittlssnlykrditsakvmnataaleflkdmkktrgrlylrpellakrpcvdiqeen
nmkalagvffdrteldrkekltftesthveiknfstekllqrikeilpqyvsafantdgg
ylfiglnedkeiigfkaemsdlddlereieksirkmpvhhfcmekkkinysckflgvydk
gslcgyvcalrverfccavfakepdswhvkdnrvmqltrkewiqfmveaepkfsssyeev
isqintslpaphswpllewqrqrhhcpglsgritytpenlcrklflqheglkqliceemd
svrkgslifsrswsvdlglqenhkvlcdallisqdsppvlytfhmvqdeefkgystqtal
tlkqklakiggytkkvcvmtkifylspegmtscqydlrsqviypesyyftrrkyllkalf
kalkrlkslrdqfsfaenlyqiigidcfqkndkkmfkscrrlt

    Sequence, based on observed residues (ATOM records):
    >7lrdC (C:)
nisvdletnyaelvldvgrvtlgensrkkmkdcklrkkqnesvsramcallnsgggvika
eienedysytkdgigldlensfsnillfvpeyldfmqngnyflifvkswslntsglritt
lssnlykrditsakvmnataaleflkdmkktrgrllakrpcvdiqeennmkalagvffdr
teldrkekltftesthveiknfstekllqrikeilpqyvsafantdggylfiglnedkei
igfkaemsdlddlereieksirkmpvhhfcmekkkinysckflgvydkgslcgyvcalrv
erfccavfakepdswhvkdnrvmqltrkewiqfmveaeritytpenlcrklflqheglkq
liceemdsvrkgslifsrswsvdlglqenhkvlcdallisqdsppvlytfhmvqdeefkg
ystqtaltlkqklakiggytkkvcvmtkifylspegmtscqydlrsqviypesyyftrrk
yllkalfkalkrlkslrdqfsfaenlyqiigi

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lrdD (D:)
gedeteclreplrkasacstyapetmmfldkpilapeplvmdnldsimeqlntwnfpifd
lvenigrkcgrilsqvsyrlfedmglfeafkipirefmnyfhaleigyrdipyhnrihat
dvlhavwylttqpipglstvindhgstsdsdsdsgfthghmgyvfsktynvtddkygcls
gnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenhhaaaawnlfm
srpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddvgidwtnendr
llvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpispfmdrsapqla
nlqesfishivgplcnsydsaglmpgkwvedsdesgdtddpeeeeeeapapneeetcenn
espkkktfkrrkiycqitqhllqnhkmwkkvieeeqrlagienqsldqtpqshsseqiqa
ikeeeeekgkprgeeiptqkpdq

    Sequence, based on observed residues (ATOM records):
    >7lrdD (D:)
kpilapeplvmdnldsimeqlntwnfpifdlvenigrkcgrilsqvsyrlfedmglfeaf
kipirefmnyfhaleigyrdipyhnrihatdvlhavwylttqpipglstvgyvfsktynv
tddkygclsgnipalelmalyvaaamhdydhpgrtnaflvatsapqavlyndrsvlenhh
aaaawnlfmsrpeynflinldhvefkhfrflvieailatdlkkhfdfvakfngkvnddvg
idwtnendrllvcqmcikladingpakckelhlqwtdgivnefyeqgdeeaslglpispf
mdrsapqlanlqesfishivgplcnsydsaglmpgkwverkiycqitqhllqnhkmwkkv
ieeeqrlagie