PDB entry 7lqv

View 7lqv on RCSB PDB site
Description: cryo-em structure of ntd-directed neutralizing antibody 4-8 fab in complex with sars-cov-2 s2p spike
Deposited on 2021-02-15, released 2021-03-24
The last revision was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: EM
Resolution: 3.25 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (32-End)
      • conflict (1004-1005)
  • Chain 'B':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (32-End)
      • conflict (1004-1005)
  • Chain 'C':
    Compound: Spike glycoprotein
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DTC2 (32-End)
      • conflict (1004-1005)
  • Chain 'H':
    Compound: 4-8 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (0-124)
  • Chain 'L':
    Compound: 4-8 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (Start-104)
  • Chain 'W':
    Compound: 4-8 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (0-124)
  • Chain 'X':
    Compound: 4-8 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (Start-104)
  • Chain 'Y':
    Compound: 4-8 Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (0-124)
  • Chain 'Z':
    Compound: 4-8 Light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LQV (Start-104)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lqvA (A:)
mgilpspgmpallslvsllsvllmgcvaetgtqcvnlttrtqlppaytnsftrgvyypdk
vfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksnii
rgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvys
sannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfs
aleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkyne
ngtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgev
fnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfv
irgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnl
kpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhap
atvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqt
leilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsn
vfqtragcligaehvnnsyecdipigagicasyqtqtnspgsassvasqsiiaytmslga
ensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfct
qlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedl
lfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagt
itsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsst
asalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrl
qslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvv
flhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntf
vsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqk
eidrlnevaknlneslidlqelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrsl
evlfqgpghhhhhhhhsawshpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7lqvA (A:)
qcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgt
ngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcef
qfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmfknlrefvfknidgyf
kiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtag
aaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvq
ptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcyg
vsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnl
dskgnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfq
qfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpva
ihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiay
tmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllq
ygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskr
sfiedllfnkvtllicaqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalq
ipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqn
aqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqlira
aeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknf
ttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnn
tvydplqpelds

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lqvB (B:)
mgilpspgmpallslvsllsvllmgcvaetgtqcvnlttrtqlppaytnsftrgvyypdk
vfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksnii
rgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvys
sannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfs
aleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkyne
ngtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgev
fnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfv
irgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnl
kpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhap
atvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqt
leilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsn
vfqtragcligaehvnnsyecdipigagicasyqtqtnspgsassvasqsiiaytmslga
ensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfct
qlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedl
lfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagt
itsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsst
asalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrl
qslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvv
flhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntf
vsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqk
eidrlnevaknlneslidlqelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrsl
evlfqgpghhhhhhhhsawshpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7lqvB (B:)
qcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgt
ngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcef
qfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmfknlrefvfknidgyf
kiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtag
aaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvq
ptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcyg
vsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnl
dskgnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfq
qfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpva
ihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiay
tmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllq
ygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskr
sfiedllfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqyts
allagtitsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiq
dslsstasalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidr
litgrlqslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqs
aphgvvflhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqii
ttdntfvsgncdvvigivnntvydplqpelds

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lqvC (C:)
mgilpspgmpallslvsllsvllmgcvaetgtqcvnlttrtqlppaytnsftrgvyypdk
vfrssvlhstqdlflpffsnvtwfhaihvsgtngtkrfdnpvlpfndgvyfasteksnii
rgwifgttldsktqsllivnnatnvvikvcefqfcndpflgvyyhknnkswmesefrvys
sannctfeyvsqpflmdlegkqgnfknlrefvfknidgyfkiyskhtpinlvrdlpqgfs
aleplvdlpiginitrfqtllalhrsyltpgdsssgwtagaaayyvgylqprtfllkyne
ngtitdavdcaldplsetkctlksftvekgiyqtsnfrvqptesivrfpnitnlcpfgev
fnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcftnvyadsfv
irgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynylyrlfrksnl
kpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvlsfellhap
atvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfqqfgrdiadttdavrdpqt
leilditpcsfggvsvitpgtntsnqvavlyqdvnctevpvaihadqltptwrvystgsn
vfqtragcligaehvnnsyecdipigagicasyqtqtnspgsassvasqsiiaytmslga
ensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllqygsfct
qlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskrsfiedl
lfnkvtladagfikqygdclgdiaardlicaqkfngltvlpplltdemiaqytsallagt
itsgwtfgagaalqipfamqmayrfngigvtqnvlyenqklianqfnsaigkiqdslsst
asalgklqdvvnqnaqalntlvkqlssnfgaissvlndilsrldppeaevqidrlitgrl
qslqtyvtqqliraaeirasanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvv
flhvtyvpaqeknfttapaichdgkahfpregvfvsngthwfvtqrnfyepqiittdntf
vsgncdvvigivnntvydplqpeldsfkeeldkyfknhtspdvdlgdisginasvvniqk
eidrlnevaknlneslidlqelgkyeqgsgyipeaprdgqayvrkdgewvllstflgrsl
evlfqgpghhhhhhhhsawshpqfekgggsggggsggsawshpqfek

    Sequence, based on observed residues (ATOM records):
    >7lqvC (C:)
qcvnlttrtqlppaytnsftrgvyypdkvfrssvlhstqdlflpffsnvtwfhaihvsgt
ngtkrfdnpvlpfndgvyfasteksniirgwifgttldsktqsllivnnatnvvikvcef
qfcndpflgvyyhknnkswmesefrvyssannctfeyvsqpflmfknlrefvfknidgyf
kiyskhtpinlvrdlpqgfsaleplvdlpiginitrfqtllalhrsyltpgdsssgwtag
aaayyvgylqprtfllkynengtitdavdcaldplsetkctlksftvekgiyqtsnfrvq
ptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcyg
vsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnl
dskgnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngv
gyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfnfngltgtgvltesnkkflpfq
qfgrdiadttdavrdpqtleilditpcsfggvsvitpgtntsnqvavlyqdvnctevpva
ihadqltptwrvystgsnvfqtragcligaehvnnsyecdipigagicasyqtsqsiiay
tmslgaensvaysnnsiaiptnftisvtteilpvsmtktsvdctmyicgdstecsnlllq
ygsfctqlnraltgiaveqdkntqevfaqvkqiyktppikdfggfnfsqilpdpskpskr
sfiedllfnkvtqkfngltvlpplltdemiaqytsallagtitsgwtfgagaalqipfam
qmayrfngigvtqnvlyenqklianqfnsaigkiqdslsstasalgklqdvvnqnaqaln
tlvkqlssnfgaissvlndilsrldppeaevqidrlitgrlqslqtyvtqqliraaeira
sanlaatkmsecvlgqskrvdfcgkgyhlmsfpqsaphgvvflhvtyvpaqeknfttapa
ichdgkahfpregvfvsngthwfvtqrnfyepqiittdntfvsgncdvvigivnntvydp
lqpelds

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >7lqvH (H:)
qvqlvqsgaevkkagssvkvsckasggtfsshtitwvrqapgqglewmgriipilgiany
aqkfqgrvtitadkststaymelsslrsedtavyycaslqtvdtaiekyygmdvwgqgtt
vtvss

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7lqvL (L:)
syeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviyqdnkrpsgiper
fsgsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl

    Sequence, based on observed residues (ATOM records):
    >7lqvL (L:)
yeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviyqdnkrpsgiperf
sgsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records:
    >7lqvW (W:)
qvqlvqsgaevkkagssvkvsckasggtfsshtitwvrqapgqglewmgriipilgiany
aqkfqgrvtitadkststaymelsslrsedtavyycaslqtvdtaiekyygmdvwgqgtt
vtvss

  • Chain 'X':
    Sequence, based on SEQRES records:
    >7lqvX (X:)
syeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviyqdnkrpsgiper
fsgsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl

    Sequence, based on observed residues (ATOM records):
    >7lqvX (X:)
yeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviydnkrpsgiperfs
gsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl

  • Chain 'Y':
    Sequence; same for both SEQRES and ATOM records:
    >7lqvY (Y:)
qvqlvqsgaevkkagssvkvsckasggtfsshtitwvrqapgqglewmgriipilgiany
aqkfqgrvtitadkststaymelsslrsedtavyycaslqtvdtaiekyygmdvwgqgtt
vtvss

  • Chain 'Z':
    Sequence, based on SEQRES records:
    >7lqvZ (Z:)
syeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviyqdnkrpsgiper
fsgsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl

    Sequence, based on observed residues (ATOM records):
    >7lqvZ (Z:)
yeltqppsvsvspgqtasitcsgdklgdkyacwyqqkpgqspvlviyqdnkrpsgiperf
sgsnsgntatltisgtqamdeadyycqawdsstavfgggtkltvl