PDB entry 7lpe

View 7lpe on RCSB PDB site
Description: cryo-em structure of full-length trpv1 with capsaicin at 48 degrees celsius, in an open state, class 1
Deposited on 2021-02-11, released 2021-07-28
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 3.72 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Heterogens: LBN, 6OU, 4DY

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lpeA (A:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lpeA (A:)
hiaierrnmtlvtllyfgelplslaactnqlaivkfllqsvgntvlhalvevadntvdnt
kfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepec
rhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrll
qdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsv
sggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmv
fslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlieds
ynslystclelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetv
nkiaqeskniwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvde
vnwttw

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lpeB (B:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lpeB (B:)
hiaierrnmtlvtllyfgelplslaactnqlaivkfllqsvgntvlhalvevadntvdnt
kfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepec
rhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrll
qdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsv
sggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmv
fslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlieds
ynslystclelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetv
nkiaqeskniwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvde
vnwttw

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lpeC (C:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lpeC (C:)
hiaierrnmtlvtllyfgelplslaactnqlaivkfllqsvgntvlhalvevadntvdnt
kfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepec
rhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrll
qdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsv
sggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmv
fslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlieds
ynslystclelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetv
nkiaqeskniwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvde
vnwttw

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lpeD (D:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lpeD (D:)
hiaierrnmtlvtllyfgelplslaactnqlaivkfllqsvgntvlhalvevadntvdnt
kfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepec
rhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrll
qdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsv
sggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmv
fslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlieds
ynslystclelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetv
nkiaqeskniwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvde
vnwttw