PDB entry 7lpb

View 7lpb on RCSB PDB site
Description: cryo-em structure of full-length trpv1 with capsaicin at 25 degrees celsius
Deposited on 2021-02-11, released 2021-07-28
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 3.54 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'B':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'C':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Chain 'D':
    Compound: Transient receptor potential cation channel subfamily V member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Trpv1, Vr1, Vr1l
    Database cross-references and differences (RAF-indexed):
    • Uniprot O35433 (0-837)
      • expression tag (838-867)
  • Heterogens: LBN, 6OU, YFP, 4DY

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lpbA (A:)
    meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
    ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
    vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
    rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
    grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
    ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
    ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
    llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
    svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
    mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
    dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
    illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
    rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
    rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
    slevlfqgpdykddddkahhhhhhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >7lpbA (A:)
    drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
    qfvnasytdsyykgqtalhiaierrnmtlvtllvenvqaaangdffkrpgfyfgelplsl
    aactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmyneili
    lgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkfteway
    gpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkrif
    yfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrgiq
    yflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnmly
    ytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystcle
    lfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqeskni
    wklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lpbB (B:)
    meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
    ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
    vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
    rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
    grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
    ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
    ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
    llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
    svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
    mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
    dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
    illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
    rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
    rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
    slevlfqgpdykddddkahhhhhhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >7lpbB (B:)
    drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
    qfvnasytdsyykgqtalhiaierrnmtlvtllvenvqaaangdffkrpgfyfgelplsl
    aactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmyneili
    lgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkfteway
    gpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkrif
    yfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrgiq
    yflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnmly
    ytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystcle
    lfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqeskni
    wklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lpbC (C:)
    meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
    ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
    vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
    rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
    grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
    ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
    ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
    llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
    svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
    mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
    dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
    illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
    rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
    rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
    slevlfqgpdykddddkahhhhhhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >7lpbC (C:)
    drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
    qfvnasytdsyykgqtalhiaierrnmtlvtllvenvqaaangdffkrpgfyfgelplsl
    aactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmyneili
    lgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkfteway
    gpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkrif
    yfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrgiq
    yflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnmly
    ytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystcle
    lfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqeskni
    wklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lpbD (D:)
    meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
    ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
    vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
    rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
    grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
    ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
    ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
    llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
    svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
    mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
    dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
    illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
    rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
    rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
    slevlfqgpdykddddkahhhhhhhhhh
    

    Sequence, based on observed residues (ATOM records):
    >7lpbD (D:)
    drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
    qfvnasytdsyykgqtalhiaierrnmtlvtllvenvqaaangdffkrpgfyfgelplsl
    aactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmyneili
    lgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkfteway
    gpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkrif
    yfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrgiq
    yflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnmly
    ytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystcle
    lfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqeskni
    wklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw