SCOPe 2.08: Structural Classification of Proteins

PDB entry 7lpa

View 7lpa on RCSB PDB site
Description: cryo-em structure of full-length trpv1 with capsaicin at 4 degrees celsius
Deposited on 2021-02-11, released 2021-07-28
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: EM
Resolution: 3.37 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Transient receptor potential cation channel subfamily V member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Trpv1, Vr1, Vr1l
Database cross-references and differences (RAF-indexed):
- Uniprot O35433 (0-837)
  - expression tag (838-867)
Chain 'B':
Compound: Transient receptor potential cation channel subfamily V member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Trpv1, Vr1, Vr1l
Database cross-references and differences (RAF-indexed):
- Uniprot O35433 (0-837)
  - expression tag (838-867)
Chain 'C':
Compound: Transient receptor potential cation channel subfamily V member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Trpv1, Vr1, Vr1l
Database cross-references and differences (RAF-indexed):
- Uniprot O35433 (0-837)
  - expression tag (838-867)
Chain 'D':
Compound: Transient receptor potential cation channel subfamily V member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Trpv1, Vr1, Vr1l
Database cross-references and differences (RAF-indexed):
- Uniprot O35433 (0-837)
  - expression tag (838-867)
Heterogens: LBN, 6OU, 4DY, YFP, NA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

Chain 'A':
Sequence, based on SEQRES records:

>7lpaA (A:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

Sequence, based on observed residues (ATOM records):

>7lpaA (A:)
drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
qfvnasytdsyykgqtalhiaierrnmtlvtllvengavqaaangdffkrpgfyfgelpl
slaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmynei
lilgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkftew
aygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkr
ifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrg
iqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnm
lyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystc
lelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqesk
niwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw

Chain 'B':
Sequence, based on SEQRES records:

>7lpaB (B:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

Sequence, based on observed residues (ATOM records):

>7lpaB (B:)
drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
qfvnasytdsyykgqtalhiaierrnmtlvtllvengavqaaangdffkrpgfyfgelpl
slaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmynei
lilgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkftew
aygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkr
ifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrg
iqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnm
lyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystc
lelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqesk
niwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw

Chain 'C':
Sequence, based on SEQRES records:

>7lpaC (C:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

Sequence, based on observed residues (ATOM records):

>7lpaC (C:)
drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
qfvnasytdsyykgqtalhiaierrnmtlvtllvengavqaaangdffkrpgfyfgelpl
slaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmynei
lilgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkftew
aygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkr
ifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrg
iqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnm
lyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystc
lelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqesk
niwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw

Chain 'D':
Sequence, based on SEQRES records:

>7lpaD (D:)
meqrasldseesesppqenscldppdrdpnckpppvkphifttrsrtrlfgkgdseeasp
ldcpyeegglascpiitvssvltiqrpgdgpasvrpssqdsvsagekpprlydrrsifda
vaqsncqelesllpflqrskkrltdsefkdpetgktcllkamlnlhngqndtiallldva
rktdslkqfvnasytdsyykgqtalhiaierrnmtlvtllvengadvqaaangdffkktk
grpgfyfgelplslaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvd
ntkfvtsmyneililgaklhptlkleeitnrkgltplalaassgkigvlayilqreihep
ecrhlsrkftewaygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnr
llqdkwdrfvkrifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeil
svsggvyfffrgiqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvas
mvfslamgwtnmlyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtlie
dgknnslpmestphkcrgsackpgnsynslystclelfkftigmgdleftenydfkavfi
illlayviltyilllnmlialmgetvnkiaqeskniwklqraitildteksflkcmrkaf
rsgkllqvgftpdgkddyrwcfrvdevnwttwntnvgiinedpgncegvkrtlsfslrsg
rvsgrnwknfalvpllrdastrdrhatqqeevqlkhytgslkpedaevfkdsmvpgeken
slevlfqgpdykddddkahhhhhhhhhh

Sequence, based on observed residues (ATOM records):

>7lpaD (D:)
drrsifdavaqsncqelesllpflqrsetgktcllkamlnlhngqndtiallldvarktk
qfvnasytdsyykgqtalhiaierrnmtlvtllvengavqaaangdffkrpgfyfgelpl
slaactnqlaivkfllqnswqpadisardsvgntvlhalvevadntvdntkfvtsmynei
lilgaklhptlkleeitnrkgltplalaassgkigvlayilqreihepecrhlsrkftew
aygpvhsslydlscidtceknsvleviaysssetpnrhdmllveplnrllqdkwdrfvkr
ifyfnffvyclymiiftaaayyrpveglppyklkntvgdyfrvtgeilsvsggvyfffrg
iqyflqrrpslkslfvdsyseilffvqslfmlvsvvlyfsqrkeyvasmvfslamgwtnm
lyytrgfqqmgiyavmiekmilrdlcrfmfvylvflfgfstavvtliedgnsynslystc
lelfkftigmgdleftenydfkavfiilllayviltyilllnmlialmgetvnkiaqesk
niwklqraitildteksflkcmrkafrsgkllqvgftpdgkddyrwcfrvdevnwttw