PDB entry 7lop

View 7lop on RCSB PDB site
Description: Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022
Class: viral protein/immune system
Keywords: SARS-CoV-2, receptor binding domain, coronavirus, COVID-19, antibody, Fab, IMMUNE SYSTEM, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on 2021-02-10, released 2021-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-02, with a file datestamp of 2021-05-28.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7lopa_
  • Chain 'B':
    Compound: CR3022 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-221)
    Domains in SCOPe 2.08: d7lopb_
  • Chain 'C':
    Compound: CR3022 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-220)
    Domains in SCOPe 2.08: d7lopc1, d7lopc2
  • Chain 'H':
    Compound: CV05-163 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-226)
  • Chain 'L':
    Compound: CV05-163 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-End)
    Domains in SCOPe 2.08: d7lopl1, d7lopl2
  • Chain 'V':
    Compound: CR3022 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-End)
    Domains in SCOPe 2.08: d7lopv1, d7lopv2
  • Chain 'W':
    Compound: CR3022 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-221)
    Domains in SCOPe 2.08: d7lopw_
  • Chain 'X':
    Compound: CV05-163 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-226)
  • Chain 'Y':
    Compound: CV05-163 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LOP (0-215)
    Domains in SCOPe 2.08: d7lopy1, d7lopy2
  • Chain 'Z':
    Compound: Spike protein S1
    Species: Severe acute respiratory syndrome coronavirus 2 [TaxId:2697049]
    Gene: S, 2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7lopz_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7lopA (A:)
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfq
ptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopA (A:)
tnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcf
tnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynyl
yrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvv
lsfellhapatvcgp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7lopB (B:)
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetry
spsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopB (B:)
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetry
spsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvssa
stkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7lopC (C:)
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastr
esgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrgecs

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7lopL (L:)
eivltqspatlslspgeratlscrasqsvssylawyqqkpgqaprlliydasnratgipa
rfsgsgsgtdftltisslepedfavyycqqrsnwppvtfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopL (L:)
eivltqspatlslspgeratlscrasqsvssylawyqqkpgqaprlliydasnratgipa
rfsgsgsgtdftltisslepedfavyycqqrsnwppvtfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnr

  • Chain 'V':
    Sequence, based on SEQRES records: (download) 
    >7lopV (V:)
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastr
esgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopV (V:)
diqltqspdslavslgeratinckssqsvlyssinknylawyqqkpgqppklliywastr
esgvpdrfsgsgsgtdftltisslqaedvavyycqqyystpytfgqgtkveikrtvaaps
vfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstys
lsstltlskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'W':
    Sequence, based on SEQRES records: (download) 
    >7lopW (W:)
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetry
spsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopW (W:)
qmqlvqsgtevkkpgeslkisckgsgygfitywigwvrqmpgkglewmgiiypgdsetry
spsfqgqvtisadksintaylqwsslkasdtaiyycaggsgistpmdvwgqgttvtvssa
stkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7lopY (Y:)
eivltqspatlslspgeratlscrasqsvssylawyqqkpgqaprlliydasnratgipa
rfsgsgsgtdftltisslepedfavyycqqrsnwppvtfgggtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgecs

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >7lopZ (Z:)
rvqptesivrfpnitnlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfk
cygvsptklndlcftnvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawns
nnldskvggnynylyrlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfq
ptngvgyqpyrvvvlsfellhapatvcgpkkstnlvknkcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lopZ (Z:)
nlcpfgevfnatrfasvyawnrkrisncvadysvlynsasfstfkcygvsptklndlcft
nvyadsfvirgdevrqiapgqtgkiadynyklpddftgcviawnsnnldskvggnynyly
rlfrksnlkpferdisteiyqagstpcngvegfncyfplqsygfqptngvgyqpyrvvvl
sfellhapatvcgp