PDB entry 7lo6

View 7lo6 on RCSB PDB site
Description: structure of cd4 mimetic bnm-iii-170 in complex with bg505 sosip.664 hiv-1 env trimer and 17b fab
Deposited on 2021-02-09, released 2021-04-14
The last revision was dated 2021-04-14, with a file datestamp of 2021-04-09.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Envelope glycoprotein BG505 SOSIP.664 gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6 (0-End)
      • engineered mutation (298)
      • engineered mutation (466)
  • Chain 'B':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (47)
      • engineered mutation (93)
  • Chain 'C':
    Compound: Envelope glycoprotein BG505 SOSIP.664 gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6 (0-End)
      • engineered mutation (298)
      • engineered mutation (466)
  • Chain 'D':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (47)
      • engineered mutation (93)
  • Chain 'E':
    Compound: Envelope glycoprotein BG505 SOSIP.664 gp120
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6 (0-End)
      • engineered mutation (298)
      • engineered mutation (466)
  • Chain 'F':
    Compound: HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41
    Species: HUMAN IMMUNODEFICIENCY VIRUS 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2N0S6
      • engineered mutation (93)
  • Chain 'G':
    Compound: 17b Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Chain 'H':
    Compound: 17b Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Chain 'I':
    Compound: 17b Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Chain 'J':
    Compound: 17b Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Chain 'K':
    Compound: 17b Fab Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Chain 'L':
    Compound: 17b Fab Heavy Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LO6 (0-End)
  • Heterogens: 5VG, NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lo6A (A:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7lo6A (A:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcncntsaitqacpkvsfepipihycap
agfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmirsenitnn
aknilvqfntpvqinctrpndirqahcnvskatwnetlgkvvkqlrkhfgnntiirfans
sggdlevtthsfncggeffycntsglfnstwisndsitlpcrikqiinmwqrigqamyap
piqgvircvsnitgliltrdggsttetfrpgggdmrdnwrselykykvvkieplgvaptr
ckr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lo6B (B:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7lo6B (B:)
gigavflgflgaagstmgaasmtltvqarnllsapeaqqhllkltvwgikqlqarvlave
rylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqiiyg
lleesqnqqekn

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lo6C (C:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7lo6C (C:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcncntsaitqacpkvsfepipihycap
agfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmirsenitnn
aknilvqfntpvqinctrpnndirqahcnvskatwnetlgkvvkqlrkhfgnntiirfan
ssggdlevtthsfncggeffycntsglfnstwisndsitlpcrikqiinmwqrigqamya
ppiqgvircvsnitgliltrdggsttetfrpgggdmrdnwrselykykvvkieplgvapt
rckr

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lo6D (D:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7lo6D (D:)
gigavflgflgaagstmgaasmtltvqarnllsglrapeaqqhllkltvwgikqlqarvl
averylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqi
iyglleesqnqqek

  • Chain 'E':
    Sequence, based on SEQRES records:
    >7lo6E (E:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvtlqctnvtnnitddmrgelkncsfn
mttelrdkkqkvyslfyrldvvqinenqgnrsnnsnkeyrlincntsaitqacpkvsfep
ipihycapagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmi
rsenitnnaknilvqfntpvqinctrpnnntrksirigpgqafyatgdiigdirqahcnv
skatwnetlgkvvkqlrkhfgnntiirfanssggdlevtthsfncggeffycntsglfns
twisntsvqgsnstgsndsitlpcrikqiinmwqrigqamyappiqgvircvsnitglil
trdggstnsttetfrpgggdmrdnwrselykykvvkieplgvaptrckrrvvgrrrrrr

    Sequence, based on observed residues (ATOM records):
    >7lo6E (E:)
nlwvtvyygvpvwkdaettlfcasdakayetekhnvwathacvptdpnpqeihlenvtee
fnmwknnmveqmhtdiislwdqslkpcvkltplcvncntsaitqacpkvsfepipihyca
pagfailkckdkkfngtgpcpsvstvqcthgikpvvstqlllngslaeeevmirsenitn
naknilvqfntpvqinctrpnndirqahcnvskatwnetlgkvvkqlrkhfgnntiirfa
nssggdlevtthsfncggeffycntsglfnstwisdsitlpcrikqiinmwqrigqamya
ppiqgvircvsnitgliltrdggsttetfrpgggdmrdnwrselykykvvkieplgvapt
rckrr

  • Chain 'F':
    Sequence, based on SEQRES records:
    >7lo6F (F:)
avgigavflgflgaagstmgaasmtltvqarnllsgivqqqsnllrapeaqqhllkltvw
gikqlqarvlaverylrdqqllgiwgcsgklicctnvpwnsswsnrnlseiwdnmtwlqw
dkeisnytqiiyglleesqnqqekneqdllald

    Sequence, based on observed residues (ATOM records):
    >7lo6F (F:)
flgflgaagstmgaasmtltvqaqhllkltvwgikqlqarvlaverylrdqqllgiwgcs
gklicctnvpwnsswsnrnlseiwdnmtwlqwdkeisnytqiiyglleesqnqqekneqd

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7lo6G (G:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrg

    Sequence, based on observed residues (ATOM records):
    >7lo6G (G:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrt

  • Chain 'H':
    Sequence, based on SEQRES records:
    >7lo6H (H:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lo6H (H:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssa

  • Chain 'I':
    Sequence, based on SEQRES records:
    >7lo6I (I:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrg

    Sequence, based on observed residues (ATOM records):
    >7lo6I (I:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrt

  • Chain 'J':
    Sequence, based on SEQRES records:
    >7lo6J (J:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lo6J (J:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssa

  • Chain 'K':
    Sequence, based on SEQRES records:
    >7lo6K (K:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrg

    Sequence, based on observed residues (ATOM records):
    >7lo6K (K:)
divmtqspatlsvspgeratlscrasesvssdlawyqqkpgqaprlliygastratgvpa
rfsgsgsgaeftltisslqsedfavyycqqynnwpprytfgqgtrleikrt

  • Chain 'L':
    Sequence, based on SEQRES records:
    >7lo6L (L:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvht
fpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7lo6L (L:)
evqlvesgaevkkpgssvkvsckasgdtfirysftwvrqapgqglewmgriitildvahy
aphlqgrvtitadkststvylelrnlrsddtavyfcagvyegeadegeydnngflkhwgq
gtlvtvssa