PDB entry 7lm9

View 7lm9 on RCSB PDB site
Description: Crystal structure of SARS-CoV spike protein receptor-binding domain in complex with a cross-neutralizing antibody CV38-142 Fab isolated from COVID-19 patient
Class: viral protein/immune system
Keywords: SARS-CoV, Antibody, Spike, Coronavirus, SARS, IMMUNE SYSTEM, VIRAL PROTEIN-IMMUNE SYSTEM complex, Cross-Neutralization, VIRAL PROTEIN
Deposited on 2021-02-05, released 2021-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-31, with a file datestamp of 2021-03-26.
Experiment type: XRAY
Resolution: 1.53 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spike glycoprotein
    Species: SARS coronavirus MA15 [TaxId:633137]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7lm9a_
  • Chain 'H':
    Compound: CV38-142 Fab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LM9 (0-225)
    Domains in SCOPe 2.08: d7lm9h_
  • Chain 'L':
    Compound: CV38-142 Fab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LM9 (0-End)
    Domains in SCOPe 2.08: d7lm9l1, d7lm9l2
  • Heterogens: FUC, NAG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7lm9A (A:)
rvvpsgdvvrfpnitnlcpfgevfnatkfpsvyawerkkisncvadysvlynstffstfk
cygvsatklndlcfsnvyadsfvvkgddvrqiapgqtgviadynyklpddfmgcvlawnt
rnidatstgnhnykyrylrhgklrpferdisnvpfspdgkpctppalncywplndygfyt
ttgigyqpyrvvvlsfellnapatvcgpklstdliknqcvnfsghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lm9A (A:)
tnlcpfgevfnatkfpsvyawerkkisncvadysvlynstffstfkcygvsatklndlcf
snvyadsfvvkgddvrqiapgqtgviadynyklpddfmgcvlawntrnidatstgnhnyk
yrylrhgklrpferdisnvpfspdgkpctppalncywplndygfytttgigyqpyrvvvl
sfellpatvcgp

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7lm9H (H:)
evqlvqsgaevkkpgeslkiscqgsgysftsywigwvrqmpgkglewmgiiypgesdtry
sssfqghvtisadksistaylqwsslkasdtamyycarirgvyssgwiggdywgqgtlvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7lm9L (L:)
diqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystprqwtfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgecs

    Sequence, based on observed residues (ATOM records): (download) 
    >7lm9L (L:)
diqmtqspsslsasvgdrvtitcrasqsissylnwyqqkpgkapklliyaasslqsgvps
rfsgsgsgtdftltisslqpedfatyycqqsystprqwtfgqgtkveikrtvaapsvfif
ppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsst
ltlskadyekhkvyacevthqglsspvtksfnrgec