PDB entry 7llb

View 7llb on RCSB PDB site
Description: Crystal structure of KPC-2 S70G/T215P mutant with hydrolyzed meropenem
Class: hydrolase
Keywords: Carbapenemase, Beta-lactamase, Hydrolase, Antibiotic Resistance, Beta-lactam, antibiotics
Deposited on 2021-02-03, released 2021-05-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbapenem-hydrolyzing beta-lactamase KPC
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla, kpc, kpc1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9F663 (0-263)
      • engineered mutation (43)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d7llba_
  • Chain 'B':
    Compound: Carbapenem-hydrolyzing beta-lactamase KPC
    Species: Klebsiella pneumoniae [TaxId:573]
    Gene: bla, kpc, kpc1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9F663 (0-263)
      • engineered mutation (43)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d7llbb_
  • Heterogens: 8YL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7llbA (A:)
tnlvaepfakleqdfggsigvyamdtgsgatvsyraeerfplcgsfkgflaaavlarsqq
qaglldtpirygknalvpwspisekylttgmtvaelsaaavqysdnaaanlllkelggpa
gltafmrsigdttfrldrwelelnsaipgdardtsspravteslqkltlgsalaapqrqq
fvdwlkgnptgnhriraavpadwavgdktgtcgvygtandyavvwptgrapivlavytra
pnkddkhseaviaaaarlaleglg

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7llbB (B:)
tnlvaepfakleqdfggsigvyamdtgsgatvsyraeerfplcgsfkgflaaavlarsqq
qaglldtpirygknalvpwspisekylttgmtvaelsaaavqysdnaaanlllkelggpa
gltafmrsigdttfrldrwelelnsaipgdardtsspravteslqkltlgsalaapqrqq
fvdwlkgnptgnhriraavpadwavgdktgtcgvygtandyavvwptgrapivlavytra
pnkddkhseaviaaaarlaleglg