PDB entry 7ljs

View 7ljs on RCSB PDB site
Description: Porcine Dihydropyrimidine dehydrogenase (DPD) complexed with 5-Ethynyluracil (5EU) - Open Form
Class: flavoprotein
Keywords: Dihydropyrimidine dehydrogenase, DPD, dehydrogenase, 5-Ethynyluracil, 5EU, inhibitor, inactivator, FLAVOPROTEIN
Deposited on 2021-01-30, released 2021-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-04-28, with a file datestamp of 2021-04-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.08: d7ljsa1, d7ljsa2, d7ljsa3, d7ljsa4, d7ljsa5
  • Chain 'B':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.08: d7ljsb1, d7ljsb2, d7ljsb3, d7ljsb4, d7ljsb5
  • Chain 'C':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.08: d7ljsc1, d7ljsc2, d7ljsc3, d7ljsc4, d7ljsc5
  • Chain 'D':
    Compound: Dihydropyrimidine dehydrogenase [NADP(+)]
    Species: Sus scrofa [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
    Domains in SCOPe 2.08: d7ljsd1, d7ljsd2, d7ljsd3, d7ljsd4, d7ljsd5
  • Heterogens: Y3G, FAD, FMN, SF4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7ljsA (A:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljsA (A:)
    apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
    ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
    lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
    mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
    nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
    gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
    vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
    dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
    ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
    finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
    pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
    adalelnlscphgmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraake
    ggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralp
    gfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieel
    qgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnerkpf
    ipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiq
    fdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >7ljsB (B:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljsB (B:)
    pvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfddi
    khttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnpl
    gltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqekm
    peaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvvn
    feielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdqg
    fytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvflv
    frkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwned
    edqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggdi
    vgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglkf
    inpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmygp
    gqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasga
    dalelnlscphmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakegg
    adgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpgf
    pilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelqg
    wdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnerkpfip
    kkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsgyqaiqfd
    pethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglp
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >7ljsC (C:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljsC (C:)
    apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
    ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
    lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
    mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
    nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
    gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
    vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
    dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
    ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
    finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
    pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
    adalelnlscphgmlacgqdpelvrnicrwvrqavqipffakltpnvtdivsiaraakeg
    gadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravttiaralpg
    fpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylksieelq
    gwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqnaafppl
    erkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcndsg
    yqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >7ljsD (D:)
    mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
    dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
    plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
    kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
    vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
    qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
    lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
    ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
    divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
    kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
    gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
    gadalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
    araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
    iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
    ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
    naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
    mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
    vnpvc
    

    Sequence, based on observed residues (ATOM records): (download)
    >7ljsD (D:)
    apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
    ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
    lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
    mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
    nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
    gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
    vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
    dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
    ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
    finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
    pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
    adalelnlscphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
    raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
    aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
    sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
    alerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcymtcnd
    sgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpl