PDB entry 7ljd

View 7ljd on RCSB PDB site
Description: allosteric modulator ly3154207 binding to dopamine-bound dopamine receptor 1 in complex with minigs protein
Deposited on 2021-01-28, released 2021-03-03
The last revision was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Engineered Gs protein alpha subunit
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJD (Start-245)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: nanobody 35
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJD
  • Chain 'R':
    Compound: D(1A) dopamine receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: DRD1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: G4C, LDP, CLR, PLM

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7ljdA (A:)
mgclgnsktedqrneekaqreankmiekqlqkdkqvyrathrllllgadnsgkstivkqm
riyhvnsgifetkfqvdkvnfhmfdvgaqrderrkwiqcfndvtaiifvvdssdynrlqe
alndfksiwnnkwlrtisvilflnkqdllaekvlagkskiedyfpefaryttpedatpep
gedprvtrakyfirdeflristasgdgrhycyphftcsvdtenarrifndcrdiiqrmhl
rqyell

    Sequence, based on observed residues (ATOM records):
    >7ljdA (A:)
tedqrneekaqreankmiekqlqkdkqvyrathrllllgadnsgkstivkqmriyhvnsg
ifetkfqvdkvnfhmfdvgaqrderrkwiqcfndvtaiifvvdssdynrlqealndfksi
wnnkwlrtisvilflnkqdllaekvlagkskiedyfpefaryttpedatpepgedprvtr
akyfirdeflristasgdgrhycyphftcsvdtenarrifndcrdiiqrmhlrqyell

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7ljdB (B:)
hhhhhhhhmgsllqseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrt
rrtlrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayap
sgnyvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttca
lwdietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghes
dinaicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrllla
gyddfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records):
    >7ljdB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records:
    >7ljdG (G:)
asnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpf
rekkffc

    Sequence, based on observed residues (ATOM records):
    >7ljdG (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records:
    >7ljdN (N:)
mqvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasis
ytgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrg
qgtqvtvsshhhhhh

    Sequence, based on observed residues (ATOM records):
    >7ljdN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvss

  • Chain 'R':
    Sequence, based on SEQRES records:
    >7ljdR (R:)
dykddddvdmgqpgngsafllapngshapdhdvtqqrdeenlyfqgasmrtlntsamdgt
glvverdfsvriltacflsllilstllgntlvcaavirfrhlrskvtnffvislavsdll
vavlvmpwkavaeiagfwpfgsfcniwvafdimcstasilnlcvisvdrywaisspfrye
rkmtpkaafilisvawtlsvlisfipvqlswhkakptspsdgnatslaetidncdsslsr
tyaisssvisfyipvaimivtytriyriaqkqirriaaleraavhakncqtttgngkpve
csqpessfkmsfkretkvlktlsvimgvfvccwlpffilncilpfcgsgetqpfcidsnt
fdvfvwfgwansslnpiiyafnadfrkafstllgcyrlcpatnnaietvsinnngaamfs
shheprgsiskecnlvyliphavgssedlkkeeaagiarpleklspalsvildydtdvsl
ekiqpitqngqhpthhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >7ljdR (R:)
svriltacflsllilstllgntlvcaavirfrhlrskvtnffvislavsdllvavlvmpw
kavaeiagfwpfgsfcniwvafdimcstasilnlcvisvdrywaisspfryerkmtpkaa
filisvawtlsvlisfipvqlswhkakpidncdsslsrtyaisssvisfyipvaimivty
triyriaqkqirriaaleraavhakncqfkretkvlktlsvimgvfvccwlpffilncil
pfccidsntfdvfvwfgwansslnpiiyafnadfrkafstllgcy