PDB entry 7lja

View 7lja on RCSB PDB site
Description: Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation
Class: METAL TRANSPORT/Immune System
Keywords: Potassium Ion Channel, METAL TRANSPORT, METAL TRANSPORT-Immune System complex
Deposited on 2021-01-28, released 2021-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-30, with a file datestamp of 2021-06-25.
Experiment type: XRAY
Resolution: 2.77 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isoform 2 of Potassium channel subfamily K member 4
    Species: Homo sapiens [TaxId:9606]
    Gene: KCNK4, TRAAK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NYG8-2
      • engineered mutation (197)
  • Chain 'B':
    Compound: Isoform 2 of Potassium channel subfamily K member 4
    Species: Homo sapiens [TaxId:9606]
    Gene: KCNK4, TRAAK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NYG8-2
      • engineered mutation (103)
      • engineered mutation (197)
  • Chain 'D':
    Compound: anti-traak antibody 13e9 fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJA (0-210)
    Domains in SCOPe 2.08: d7ljad1, d7ljad2
  • Chain 'E':
    Compound: anti-traak antibody 13e9 fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJA (0-216)
    Domains in SCOPe 2.08: d7ljae_
  • Chain 'F':
    Compound: anti-traak antibody 13e9 fab fragment light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJA (0-210)
    Domains in SCOPe 2.08: d7ljaf1, d7ljaf2
  • Chain 'G':
    Compound: anti-traak antibody 13e9 fab fragment heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJA (0-End)
    Domains in SCOPe 2.08: d7ljag_
  • Heterogens: TL, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7ljaD (D:)
qivltqspaimsaspgekvtmtcsasssvsymhwyqqksgtspkrwiydtsklasgvpar
fsgsgsgtsysltissmeaedaatyycqqwsnspptfgagaklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7ljaE (E:)
evqlqqsgpelvkpgasmktsckvsgysftgyimnwvkqrhgknlewiglinpntgytty
nqkfkgkatltvdkssstaymellsltsedsaiyyctrgnyvfdywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpssswpsetvtcnvahpasstkvdkkivprd

    Sequence, based on observed residues (ATOM records): (download) 
    >7ljaE (E:)
evqlqqsgpelvkpgasmktsckvsgysftgyimnwvkqrhgknlewiglinpntgytty
nqkfkgkatltvdkssstaymellsltsedsaiyyctrgnyvfdywgqgttltvssaktt
ppsvyplapnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvtv
pssswpsetvtcnvahpasstkvdkkivprd

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >7ljaF (F:)
qivltqspaimsaspgekvtmtcsasssvsymhwyqqksgtspkrwiydtsklasgvpar
fsgsgsgtsysltissmeaedaatyycqqwsnspptfgagaklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >7ljaG (G:)
evqlqqsgpelvkpgasmktsckvsgysftgyimnwvkqrhgknlewiglinpntgytty
nqkfkgkatltvdkssstaymellsltsedsaiyyctrgnyvfdywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpssswpsetvtcnvahpasstkvdkkivprd

    Sequence, based on observed residues (ATOM records): (download) 
    >7ljaG (G:)
evqlqqsgpelvkpgasmktsckvsgysftgyimnwvkqrhgknlewiglinpntgytty
nqkfkgkatltvdkssstaymellsltsedsaiyyctrgnyvfdywgqgttltvssaktt
ppsvyplapnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvtv
pssswpsetvtcnvahpasstkvdkkivpr