PDB entry 7lhw

View 7lhw on RCSB PDB site
Description: structure of the lrrk2 monomer
Deposited on 2021-01-26, released 2021-06-16
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: EM
Resolution: 3.7 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Leucine-rich repeat serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: LRRK2, PARK8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5S007 (0-2526)
      • variant (49)
      • variant (1646)
      • variant (2396)
  • Heterogens: ATP, GDP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lhwA (A:)
    masgscqgceedeetlkklivrlnnvqegkqietlvqiledllvftysehasklfqgkni
    hvpllivldsymrvasvqqvgwsllcklievcpgtmqslmgpqdvgndwevlgvhqlilk
    mltvhnasvnlsviglktldllltsgkitllildeesdifmlifdamhsfpandevqklg
    ckalhvlfervseeqltefvenkdymillsaltnfkdeeeivlhvlhclhslaipcnnve
    vlmsgnvrcynivveamkafpmseriqevsccllhrltlgnffnilvlnevhefvvkavq
    qypenaalqisalsclalltetiflnqdleeknenqenddegeedklfwleacykaltwh
    rknkhvqeaacwalnnllmyqnslhekigdedghfpahrevmlsmlmhssskevfqasan
    alstlleqnvnfrkillskgihlnvlelmqkhihspevaesgckmlnhlfegsntsldim
    aavvpkiltvmkrhetslpvqlealrailhfivpgmpeesredtefhhklnmvkkqcfkn
    dihklvlaalnrfignpgiqkcglkvissivhfpdalemlslegamdsvlhtlqmypddq
    eiqclglsligylitkknvfigtghllakilvsslyrfkdvaeiqtkgfqtilailklsa
    sfskllvhhsfdlvifhqmssnimeqkdqqflnlcckcfakvamddylknvmleracdqn
    nsimvecllllgadanqakegsslicqvcekesspklvelllnsgsreqdvrkaltisig
    kgdsqiislllrrlaldvannsiclggfcigkvepswlgplfpdktsnlrkqtniastla
    rmviryqmksaveegtasgsdgnfsedvlskfdewtfipdssmdsvfaqsddldsegseg
    sflvkkksnsisvgefyrdavlqrcspnlqrhsnslgpifdhedllkrkrkilssddslr
    ssklqshmrhsdsisslasereyitsldlsanelrdidalsqkccisvhlehleklelhq
    naltsfpqqlcetlkslthldlhsnkftsfpsyllkmscianldvsrndigpsvvldptv
    kcptlkqfnlsynqlsfvpenltdvvekleqlilegnkisgicsplrlkelkilnlsknh
    isslsenfleacpkvesfsarmnflaampflppsmtilklsqnkfscipeailnlphlrs
    ldmssndiqylpgpahwkslnlrellfshnqisildlsekaylwsrveklhlshnklkei
    ppeigclenltsldvsynlelrsfpnemgklskiwdlpldelhlnfdfkhigckakdiir
    flqqrlkkavpynrmklmivgntgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqi
    rdkrkrdlvlnvwdfagreefysthphfmtqralylavydlskgqaevdamkpwlfnika
    rassspvilvgthldvsdekqrkacmskitkellnkrgfpairdyhfvnateesdalakl
    rktiineslnfkirdqlvvgqlipdcyvelekiilserknvpiefpvidrkrllqlvren
    qlqldenelphavhflnesgvllhfqdpalqlsdlyfvepkwlckimaqiltvkvegcpk
    hpkgiisrrdvekflskkrkfpknymtqyfkllekfqialpigeeyllvpsslsdhrpvi
    elphcenseiiirlyempyfpmgfwsrlinrlleispymlsgreralrpnrmywrqgiyl
    nwspeayclvgsevldnhpesflkitvpscrkgcillgqvvdhidslmeewfpglleidi
    cgegetllkkwalysfndgeehqkillddlmkkaeegdllvnpdqprltipisqiapdli
    ladlprnimlnndelefeqapefllgdgsfgsvyraayegeevavkifnkhtslrllrqe
    lvvlchlhhpslisllaagirprmlvmelaskgsldrllqqdkasltrtlqhrialhvad
    glrylhsamiiyrdlkphnvllftlypnaaiiakiadygiaqyccrmgiktsegtpgfra
    pevargnviynqqadvysfglllydilttggriveglkfpnefdeleiqgklpdpvkeyg
    capwpmveklikqclkenpqerptsaqvfdilnsaelvcltrrillpknvivecmvathh
    nsrnasiwlgcghtdrgqlsfldlntegytseevadsrilclalvhlpvekeswivsgtq
    sgtllvintedgkkrhtlekmtdsvtclycnsfskqskqknfllvgtadgklaifedktv
    klkgaaplkilnignvstplmclsestnsternvmwggcgtkifsfsndftiqklietrt
    sqlfsyaafsdsniitvvvdtalyiakqnspvvevwdkkteklcglidcvhflrevtvke
    nkeskhkmsysgrvktlclqkntalwigtggghillldlstrrlirviynfcnsvrvmmt
    aqlgslknvmlvlgynrkntegtqkqkeiqscltvwdinlphevqnlekhievrkelaek
    mrrtsve
    

    Sequence, based on observed residues (ATOM records):
    >7lhwA (A:)
    ndihklvlaalnrfignpgiqkcglkvissivhfpdalgamdsvlhtlqmypddqeiqcl
    glsligyghllakilvsslyrfkdvaeiqtkgfqtilailklsasfskllvhhsfdlvif
    hqmssnimeqkdqqflnlcckcfakvamddylknvmleracdqnnsimvecllllgadan
    qakegsslicqvcekesspklvelllnsgsreqdvrkaltisigkgdsqiislllrrlal
    dvannsiclggfcigkvepswlgplfpdktsnlrkqtniastlarmviryqmksaveere
    yitsldlsanelrdidalsqkccisvhlehleklelhqnaltsfpqqlcetlkslthldl
    hsnkftsfpsyllkmscianldvsrndigpsvvldptvkcptlkqfnlsynqlsfvpenl
    tdvvekleqlilegnkisgicsplrlkelkilnlsknhisslsenfleacpkvesfsarm
    nflaampflppsmtilklsqnkfscipeailnlphlrsldmssndiqylpgpahwkslnl
    rellfshnqisildlsekaylwsrveklhlshnklkeippeigclenltsldvsynlelr
    sfpnemgklskiwdlpldelhlnfdfkhigckakdiirflqqrlkkavpynrmklmivgn
    tgsgkttllqqlmktkksdlgmqsatvgidvkdwpiqirdkrkrdlvlnvwdfagreefy
    sthphfmtqralylavydlskgqaevdamkpwlfnikarassspvilvgthldvskacms
    kitkellnkrgfpairdyhfvnateesdalaklrktiineslnfkirdqlvvgqlipdcy
    velekiilserknvpiefpvidrkrllqlvrenqlqldenelphavhflnesgvllhfqd
    palqlsdlyfvepkwlckimaqiltvkvegcpkhpkgiisrrdpknymtqyfkllekfqi
    alvpsslsdhrpvielphcenseiiirlyempyfpmgfwsrlinrlleispymlalrpnr
    mywrqgiylnwspeayclvgsevldnhpesflkitvpscrkgcillgqvvdhidslmeew
    fpglleidicgegetllkkwalysfndgeehqkillddlmkkaeegdllvnpdqprltip
    isqiapdliladlprnimlnndelefeqapefllgdgsfgsvyraayegeevavkifnkh
    tslrllrqelvvlchlhhpslisllaagirprmlvmelaskgsldrllqqdkasltrtlq
    hrialhvadglrylhsamiiyrdlkphnvllftlypnaaiiakiadygiaqyccrmtseg
    tpgfrapevargnviynqqadvysfglllydilttggriveglkfpnefdeleiqgklpd
    pvkeygcapwpmveklikqclkenpqerptsaqvfdilnsaelvcltrrillpknvivec
    mvathhnsrnasiwlgcghtdrgqlsfldlntegytseevadsrilclalvhlpvekesw
    ivsgtqsgtllvintedgkkrhtlekmtdsvtclycnsfskqskqknfllvgtadgklai
    fedktvklkgaaplkilnignvstplmclsestnsternvmwggcgtkifsfsndftiqk
    lietrtsqlfsyaafsdsniitvvvdtalyiakqnspvvevwdkkteklcglidcvhflr
    evtvkenkeskhkmsysgrvktlclqkntalwigtggghillldlstrrlirviynfcns
    vrvmmtaqlgslknvmlvlgynrkntegtqkqkeiqscltvwdinlphevqnlekhievr
    kelaekmrrtsve