PDB entry 7lfy

View 7lfy on RCSB PDB site
Description: cryo-em structure of human cgmp-bound open cnga1 channel in na+
Deposited on 2021-01-19, released 2021-03-10
The last revision was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: EM
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-gated cation channel alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: CNGA1, CNCG, CNCG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: cGMP-gated cation channel alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: CNGA1, CNCG, CNCG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: cGMP-gated cation channel alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: CNGA1, CNCG, CNCG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: cGMP-gated cation channel alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: CNGA1, CNCG, CNCG1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NA, PCG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >7lfyA (A:)
mdykddddkggsaskdkkeeekkevvvidpsgntyynwlfcitlpvmynwtmviaracfd
elqsdyleywlildyvsdivylidmfvrtrtgyleqgllvkeelklinkyksnlqfkldv
lsliptdllyfklgwnypeirlnrllrfsrmfeffqrtetrtnypnifrisnlvmyivii
ihwnacvfysiskaigfgndtwvypdindpefgrlarkyvyslywstltlttigetpppv
rdseyvfvvvdfligvlifativgnigsmisnmnaaraefqaridaikqymhfrnvskdm
ekrvikwfdylwtnkktvdekevlkylpdklraeiainvhldtlkkvrifadceagllve
lvlklqpqvyspgdyickkgdigremyiikegklavvaddgvtqfvvlsdgsyfgeisil
nikgskagnrrtaniksigysdlfclskddlmealteypdaktmleekgkqilmkdglld
lnianagsdpkdleekvtrmegsvdllqtrfarilaeyesmqqklkqrltkvekflkpli
dtefssiegpgaesgpidst

    Sequence, based on observed residues (ATOM records):
    >7lfyA (A:)
vvidpsgntyynwlfcitlpvmynwtmviaracfdelqsdyleywlildyvsdivylidm
fvrtrtgyleqgllvkeelklinkyksnlqfkldvlsliptdllyfklgwnypeirlnrl
lrfsrmfeffqrtetrtnypnifrisnlvmyiviiihwnacvfysiskaigfgndtwvyp
dindpefgrlarkyvyslywstltlttigetpppvrdseyvfvvvdfligvlifativgn
igsmisnmnaaraefqaridaikqymhfrnvskdmekrvikwfdylwtnkktvdekevlk
ylpdklraeiainvhldtlkkvrifadceagllvelvlklqpqvyspgdyickkgdigre
myiikegklavvaddgvtqfvvlsdgsyfgeisilnikgskagnrrtaniksigysdlfc
lskddlmealteypdaktmleekgkqilmk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >7lfyB (B:)
mdykddddkggsaskdkkeeekkevvvidpsgntyynwlfcitlpvmynwtmviaracfd
elqsdyleywlildyvsdivylidmfvrtrtgyleqgllvkeelklinkyksnlqfkldv
lsliptdllyfklgwnypeirlnrllrfsrmfeffqrtetrtnypnifrisnlvmyivii
ihwnacvfysiskaigfgndtwvypdindpefgrlarkyvyslywstltlttigetpppv
rdseyvfvvvdfligvlifativgnigsmisnmnaaraefqaridaikqymhfrnvskdm
ekrvikwfdylwtnkktvdekevlkylpdklraeiainvhldtlkkvrifadceagllve
lvlklqpqvyspgdyickkgdigremyiikegklavvaddgvtqfvvlsdgsyfgeisil
nikgskagnrrtaniksigysdlfclskddlmealteypdaktmleekgkqilmkdglld
lnianagsdpkdleekvtrmegsvdllqtrfarilaeyesmqqklkqrltkvekflkpli
dtefssiegpgaesgpidst

    Sequence, based on observed residues (ATOM records):
    >7lfyB (B:)
vvidpsgntyynwlfcitlpvmynwtmviaracfdelqsdyleywlildyvsdivylidm
fvrtrtgyleqgllvkeelklinkyksnlqfkldvlsliptdllyfklgwnypeirlnrl
lrfsrmfeffqrtetrtnypnifrisnlvmyiviiihwnacvfysiskaigfgndtwvyp
dindpefgrlarkyvyslywstltlttigetpppvrdseyvfvvvdfligvlifativgn
igsmisnmnaaraefqaridaikqymhfrnvskdmekrvikwfdylwtnkktvdekevlk
ylpdklraeiainvhldtlkkvrifadceagllvelvlklqpqvyspgdyickkgdigre
myiikegklavvaddgvtqfvvlsdgsyfgeisilnikgskagnrrtaniksigysdlfc
lskddlmealteypdaktmleekgkqilmk

  • Chain 'C':
    Sequence, based on SEQRES records:
    >7lfyC (C:)
mdykddddkggsaskdkkeeekkevvvidpsgntyynwlfcitlpvmynwtmviaracfd
elqsdyleywlildyvsdivylidmfvrtrtgyleqgllvkeelklinkyksnlqfkldv
lsliptdllyfklgwnypeirlnrllrfsrmfeffqrtetrtnypnifrisnlvmyivii
ihwnacvfysiskaigfgndtwvypdindpefgrlarkyvyslywstltlttigetpppv
rdseyvfvvvdfligvlifativgnigsmisnmnaaraefqaridaikqymhfrnvskdm
ekrvikwfdylwtnkktvdekevlkylpdklraeiainvhldtlkkvrifadceagllve
lvlklqpqvyspgdyickkgdigremyiikegklavvaddgvtqfvvlsdgsyfgeisil
nikgskagnrrtaniksigysdlfclskddlmealteypdaktmleekgkqilmkdglld
lnianagsdpkdleekvtrmegsvdllqtrfarilaeyesmqqklkqrltkvekflkpli
dtefssiegpgaesgpidst

    Sequence, based on observed residues (ATOM records):
    >7lfyC (C:)
vvidpsgntyynwlfcitlpvmynwtmviaracfdelqsdyleywlildyvsdivylidm
fvrtrtgyleqgllvkeelklinkyksnlqfkldvlsliptdllyfklgwnypeirlnrl
lrfsrmfeffqrtetrtnypnifrisnlvmyiviiihwnacvfysiskaigfgndtwvyp
dindpefgrlarkyvyslywstltlttigetpppvrdseyvfvvvdfligvlifativgn
igsmisnmnaaraefqaridaikqymhfrnvskdmekrvikwfdylwtnkktvdekevlk
ylpdklraeiainvhldtlkkvrifadceagllvelvlklqpqvyspgdyickkgdigre
myiikegklavvaddgvtqfvvlsdgsyfgeisilnikgskagnrrtaniksigysdlfc
lskddlmealteypdaktmleekgkqilmk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >7lfyD (D:)
mdykddddkggsaskdkkeeekkevvvidpsgntyynwlfcitlpvmynwtmviaracfd
elqsdyleywlildyvsdivylidmfvrtrtgyleqgllvkeelklinkyksnlqfkldv
lsliptdllyfklgwnypeirlnrllrfsrmfeffqrtetrtnypnifrisnlvmyivii
ihwnacvfysiskaigfgndtwvypdindpefgrlarkyvyslywstltlttigetpppv
rdseyvfvvvdfligvlifativgnigsmisnmnaaraefqaridaikqymhfrnvskdm
ekrvikwfdylwtnkktvdekevlkylpdklraeiainvhldtlkkvrifadceagllve
lvlklqpqvyspgdyickkgdigremyiikegklavvaddgvtqfvvlsdgsyfgeisil
nikgskagnrrtaniksigysdlfclskddlmealteypdaktmleekgkqilmkdglld
lnianagsdpkdleekvtrmegsvdllqtrfarilaeyesmqqklkqrltkvekflkpli
dtefssiegpgaesgpidst

    Sequence, based on observed residues (ATOM records):
    >7lfyD (D:)
vvidpsgntyynwlfcitlpvmynwtmviaracfdelqsdyleywlildyvsdivylidm
fvrtrtgyleqgllvkeelklinkyksnlqfkldvlsliptdllyfklgwnypeirlnrl
lrfsrmfeffqrtetrtnypnifrisnlvmyiviiihwnacvfysiskaigfgndtwvyp
dindpefgrlarkyvyslywstltlttigetpppvrdseyvfvvvdfligvlifativgn
igsmisnmnaaraefqaridaikqymhfrnvskdmekrvikwfdylwtnkktvdekevlk
ylpdklraeiainvhldtlkkvrifadceagllvelvlklqpqvyspgdyickkgdigre
myiikegklavvaddgvtqfvvlsdgsyfgeisilnikgskagnrrtaniksigysdlfc
lskddlmealteypdaktmleekgkqilmk