PDB entry 7les

View 7les on RCSB PDB site
Description: Acanthamoeba castellanii CYP51 (AcCYP51)-Imidazole complex
Class: oxidoreductase
Keywords: cyp51, ergosterol biosynthesis, Acanthamoeba, 14-alpha-demethylase, OXIDOREDUCTASE
Deposited on 2021-01-15, released 2021-12-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-07-20, with a file datestamp of 2022-07-15.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Obtusifoliol 14alphademethylase, putative
    Species: Acanthamoeba castellanii str. Neff [TaxId:1257118]
    Gene: ACA1_372720
    Database cross-references and differences (RAF-indexed):
    • Uniprot L8GJB3 (10-453)
      • initiating methionine (0)
      • expression tag (1-9)
      • expression tag (454-459)
    Domains in SCOPe 2.08: d7lesa1, d7lesa2, d7lesa3
  • Chain 'B':
    Compound: Obtusifoliol 14alphademethylase, putative
    Species: Acanthamoeba castellanii str. Neff [TaxId:1257118]
    Gene: ACA1_372720
    Database cross-references and differences (RAF-indexed):
    • Uniprot L8GJB3 (10-453)
      • initiating methionine (0)
      • expression tag (1-9)
      • expression tag (454-459)
    Domains in SCOPe 2.08: d7lesb1, d7lesb2, d7lesb3
  • Chain 'C':
    Compound: Obtusifoliol 14alphademethylase, putative
    Species: Acanthamoeba castellanii str. Neff [TaxId:1257118]
    Gene: ACA1_372720
    Database cross-references and differences (RAF-indexed):
    • Uniprot L8GJB3 (10-453)
      • initiating methionine (0)
      • expression tag (1-9)
      • expression tag (454-459)
    Domains in SCOPe 2.08: d7lesc1, d7lesc2, d7lesc3
  • Chain 'D':
    Compound: Obtusifoliol 14alphademethylase, putative
    Species: Acanthamoeba castellanii str. Neff [TaxId:1257118]
    Gene: ACA1_372720
    Database cross-references and differences (RAF-indexed):
    • Uniprot L8GJB3 (10-453)
      • initiating methionine (0)
      • expression tag (1-9)
      • expression tag (454-459)
    Domains in SCOPe 2.08: d7lesd1, d7lesd2, d7lesd3
  • Heterogens: IMD, HEM, PEG, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7lesA (A:)
makktsskgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflv
gpdahvpffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqs
yvplivkeaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtl
degllpisvffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdary
rgeeqalndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirk
efgdeltmealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspa
lsmrveevfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvll
rnfdielvgelpkpdytamvvgpahpcllrytrkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lesA (A:)
kgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflvgpdahvp
ffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqsyvplivk
eaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtldegllpi
svffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdaryrgeeqal
ndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirkefgdelt
mealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspalsmrvee
vfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvllrnfdiel
vgelpkpdytamvvgpahpcllrytrkhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7lesB (B:)
makktsskgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflv
gpdahvpffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqs
yvplivkeaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtl
degllpisvffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdary
rgeeqalndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirk
efgdeltmealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspa
lsmrveevfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvll
rnfdielvgelpkpdytamvvgpahpcllrytrkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lesB (B:)
kgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflvgpdahvp
ffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqsyvplivk
eaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtldegllpi
svffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdaryrgeeqal
ndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirkefgdelt
mealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspalsmrvee
vfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvllrnfdiel
vgelpkpdytamvvgpahpcllrytrkh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7lesC (C:)
makktsskgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflv
gpdahvpffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqs
yvplivkeaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtl
degllpisvffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdary
rgeeqalndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirk
efgdeltmealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspa
lsmrveevfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvll
rnfdielvgelpkpdytamvvgpahpcllrytrkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lesC (C:)
kgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflvgpdahvp
ffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqsyvplivk
eaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtldegllpi
svffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdaryrgeeqal
ndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirkefgdelt
mealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspalsmrvee
vfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvllrnfdiel
vgelpkpdytamvvgpahpcllrytrkhh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >7lesD (D:)
makktsskgklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflv
gpdahvpffsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqs
yvplivkeaedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtl
degllpisvffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdary
rgeeqalndeeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirk
efgdeltmealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspa
lsmrveevfpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvll
rnfdielvgelpkpdytamvvgpahpcllrytrkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7lesD (D:)
gklppvvsslipfvgsglsfaggplqyttdaykkygdiftmkvfgqrltflvgpdahvpf
fsqgdaelsqdepyqfsvpifgpnvvygadlahrnqqlkfiaaslstkalqsyvplivke
aedffakwdksgtvdirdalaeliiltasrclmgkeirenlftevaklyqtldegllpis
vffpylpipahkrrdearlamvrmfkkiiderranpevkhndclqvfmdaryrgeeqaln
deeitglmiallfagqhtssvtgswtglllfeannkkkflpgvleeqeeirkefgdeltm
ealnkmdklhrcvkealrmyppllfvmrkvikpfsykdyyvpegdtvfvspalsmrveev
fpnadqynperfveedkqaqkyrfvgfgagrhgcmgenfaylqiktiwsvllrnfdielv
gelpkpdytamvvgpahpcllrytrkh